SNP Microarray Service

CD genomics can help you analyze genetic variation efficiently to meet diverse research needs. By utilizing Affymetrix and Illumina array platforms, we support high-throughput, multiplex processing to meet diverse research needs., delivering high-quality data at a low per-sample cost.

What is a SNP Microarray Test

Single Nucleotide Polymorphism (SNP) microarray represents a sophisticated, high-throughput genomic technology adept at detecting and analyzing single nucleotide polymorphisms across the human genome. SNPs constitute the most prevalent form of genetic variation among individuals, characterized by the alteration of a single nucleotide within the DNA sequence. These tiny genomic alterations can exert significant influence on a wide spectrum of biological traits, encompassing disease susceptibility and pharmacogenomic response.

SNP Microarray Detection Principles:

• Chip Composition: The microarray primarily consists of fiber optic strands and nanomaterials, such as silicon beads, which form the core components of the chip.
• Technical Principles: The chip integrates numerous known sequence probes. These probes hybridize with fluorescently labeled DNA molecules from samples to detect hybridization signals. This process facilitates the acquisition of sequence information.

CD Genomics harnesses state-of-the-art SNP microarray technology to deliver precise and comprehensive genetic analyses. By employing high-density array platforms, CD Genomics provides detailed insights into genetic variations, which may elucidate the molecular underpinnings of diverse phenotypes and medical conditions. This advanced technology facilitates the identification of critical genomic loci responsible for disease predisposition and therapeutic responsiveness, potentially guiding preventative strategies and personalized medical interventions.

The Introduction to SNP Microarray Service

Equipped with advanced variant detection and SNP genotyping technologies, CD Genomics offers a suite of genotyping services that deliver high-quality data at competitive per-sample costs. SNP microarrays are an invaluable tool for researchers, facilitating the exploration of genetic variants—including SNPs and significant structural changes—across a spectrum of applications, from initial discovery to routine screening.

Both Affymetrix and Illumina genotyping microarrays are known for their reliable performance, making them suitable for precision medicine initiatives, clinical and translational research, pharmacology, consumer screening, and agricultural applications. Depending on the species and the specific SNP selection, a range of genotyping strategies can be employed to meet diverse research needs.

Table 1. Our available automated SNP genotyping platforms.

	Platform	Applications
	GeneTitan instrument together with Axiom array plates	The model organism studies Agricultural genotyping CarrierScan Assay Mouse Diversity Genotyping
	GeneChip Scanner 3000 7G System together with Affymetrix GeneChip	Precision Medicine Research The detection of all known microorganisms ADME
	Illumina iScan system together with Illumina BeadChips	GWAS exonic content studies population-scale studies CNV and LOH Agricultural genotyping

Figure 1. Diagram of the location of HLA-encoding genes.

Advantages of Our SNP Microarray Service

• Custom, flexible, and scalable
• High call rates > 99%, and high accuracy
• Cost-effective and high-throughput
• High Resolution and Accuracy
• Broad Coverage and Flexibility
• Rapid Turnaround Time
• Comprehensive Data Interpretation
• Identifies SNPs in targeted or whole genome scale
• In addition to SNPs, other genetic differences, such as copy number variations, can be measured
• Applications in biomarker discovery and validation, clinical testing, GWAS, pharmacogenomics, forensics, and breed discrimination

Applications of SNP Microarray

• Genetic Research: SNP microarrays provide a detailed view of genetic variations linked to specific diseases and traits, driving forward our knowledge of genetic influences and mechanisms.
• Personalized Medicine: By analyzing individual genetic profiles, SNP microarrays enable customized treatment plans, improving drug effectiveness and reducing the risk of adverse drug reactions.
• Population Genetics and Evolutionary Studies: These arrays offer insights into genetic diversity and evolutionary changes across different populations, helping to trace migration patterns and evolutionary developments.
• Clinical Diagnostics: SNP microarrays are instrumental in diagnosing genetic conditions and evaluating disease risks, facilitating early intervention and tailored healthcare strategies.
• Agriculture and Animal Breeding: In agriculture, SNP microarrays are used to enhance desirable traits in crops and livestock, leading to better yields and improved resistance to diseases.

SNP Microarray Workflow

The general workflow for SNP Microarray is outlined below. We have three well-recognized genotyping platforms (Table 1) for genome-wide or targeted identification of SNPs and copy number variations in a high-throughput and affordable manner. Our highly experienced expert team executes quality management, following every procedure to ensure confident and unbiased results.

	Sample Requirements Genomic DNA≥300 ng, Minimum Quantity: 100 ng, concentration≥8 ng/µL DNA samples require an OD260/280 as close to 1.8~2.0 as possible. All DNA should be RNase-treated and should show no degradation or contamination. Note: Sample amounts are listed for reference only. For detailed information, please contact us with your customized requests.
Click	SNP Genotyping A wide range of arrays are available for humans, plants, and animals, or Custom genotyping arrays panels can be created to fully meet your specific needs GeneTitan instrument GeneChip Scanner Illumina iScan Accuracy and reliability for the assays are usually above 99.5%
	Bioinformatics Analysis We provide multiple customized bioinformatics analyses: SNP identification GWAS Linkage map construction Genomic selection Population structure analysis Note: Recommended data outputs and analysis contents displayed are for reference only. For detailed information, please contact us with your customized requests.

Analysis Pipeline

Deliverables

• The original sequencing data
• Experimental results
• Data analysis report
• Details in SNP Microarray for your writing (customization)

Our full-service offering encompasses the entire workflow, from quality control of genomic DNA to the precise determination of genotypes. Additionally, CD Genomics provides the capability to design custom microarrays tailored to meet unique project requirements. For further inquiries or additional specifications, please do not hesitate to contact our team.