New Strategies for Cancer Research
Cancer is the second most deadly disease in humans, with approximately 13% of patients worldwide dying of cancer each year. The basic goal of cancer research is to elucidate the mechanisms of cancer development and to develop appropriate diagnostic, therapeutic, and preventive strategies. Our high-throughput sequencing technology and functional genomics provide important, valuable genomic data related to cancer to find potential drug targets and develop more individualized treatment.
Benefits of Tumor Genomics
Tumor genomics provides an important basis for tumor molecular typing and individualized treatment. Tumor genomics research can not only provide a theoretical basis for the occurrence of tumors, but also provide clues for the diagnosis and prevention of malignant tumors. Multiple genetic mutations have been identified using cancer genomics, and their correlation with clinical phenotype can be deduced. In particular, cancer-related mutations that occur at an early stage will have a significant impact on clinical diagnosis. Genomics-based methods have been widely used in cancer research, diagnosis, and personalized medicine.
Genomics Solutions in the Oncology Research Field
Oncology Genomics Methods
Whole genome sequencing, whole exome sequencing, targeted sequencing, and circulating tumor DNA sequencing are used to capture genomic changes in tumor tissue, allowing to understand oncogenes, tumor suppressor genes, and other genetic factors that have an impact on cancer progression.
Cancer RNA Expression
Monitoring changes in gene expression can be used to diagnose and characterize tumors. Related sequencing technologies include RNA-seq, small RNA sequencing, lncRNA sequencing, circRNA sequencing, targeted RNA sequencing, exosomal RNA sequencing, degradome sequencing, etc.
Cancer epigenomics is used to explore methylation abnormalities and transcription factor binding in tumor. Related technologies include whole-genome bisulfite sequencing, targeted bisulfite sequencing, MeDIP sequencing, reduced representative bisulfite sequencing, ChIP-seq, ATAC-seq, NGS-BSP, etc.
Single cell sequencing allows us to obtain whole genomes at the single cell level. The development of single-cell sequencing technology provides a new way to understand the tumor more deeply, and it is expected to find a more effective method for the diagnosis and treatment of tumors.