CD Genomics provides a fully flexible genotyping service for small, large, standard or customized projects, on humans and many other species. Our powerful portfolio includes arrays, reagents, instruments and bioinformatics tools that enable you to detect common and rare single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and other genetic variations. CD Genomics genotyping services accommodate projects with a broad range of applications. With more than 10 years of service experience, we offer a highly trusted, flexible and competent service combined with high industry standards and scalable capacity, and we have been recognized as the premium choice of SNP genotyping.
Single Nucleotide Polymorphisms (SNPs) are bi-allelic (usually) nucleotide variants that have been found throughout the genome at a frequency of about one in 1,000 bp. They can be found in coding, non-coding, and intronic regions of genomes, and they may affect transcription factor binding, gene splicing, protein folding, and many other elements at the gene and transcript level. Hence they may be responsible for the diversity among individuals and genome evolution, and are ideal markers for identifying genes associated with complex diseases. SNPs are one of the two most common sources of genetic variation (the second one are copy number variants, CNVs). SNP analysis is important and quite meaningful for studies such as disease related genetics, individualized health management, breeding, etc.
On the basis of the purposes of the study, SNP genotyping can be divided into two domains, whole genome genotyping and fine mapping. Whole genome genotyping is a platform for screening SNPs. Fine mapping here is defined as SNP genotyping analysis at a high density for selective genomic regions. Fine mapping often follows large-scale genome-wide studies to zoom into potential genes associated with the disease of interest, and requires the validation of fewer (e.g., fewer than 1,000) SNPs highly specific for each disease for a larger sample size, it should achieve a high call rate for all selected SNPs, without time-consuming assay optimization processes, and at a relatively high multiplex level.
A key issue in high-throughput genotyping is to choose the appropriate technology for your goals and for the stage of your experiment. CD genomics offers researchers the flexibility to profile samples with thousands to millions of markers in high-throughput format, and deliver dense genome-wide coverage with the most up-to-date content available from the scientific community.
We offer different genotyping technologies depending on the application and species, the purpose of the analysis, the number of SNPs per sample (from just a few up to five million) and the number of samples in the study. Our comprehensive SNP genotyping services include both whole genome wide assay for SNP screening and fine mapping assay for validation of SNPs based on 5 platforms—Affymetrix, Illumina, Sequenom MassARRAY, ABI TaqMan, and ABI 3730XL:
Our service package includes:
We aim to provide the highest level of service, confidentiality and customer support. Our extensive expertise can help expedite your SNP and mutation analysis assays with speed, quality, and reliability. With our services you can either take a deep look into the genome or search for unknown genotype-phenotype connections or genotype already known variations.