Drug development has now entered into the era of big data due to the continued advancements in the next-generation sequencing (NGS) and other genomic technologies. Based on a full portfolio of sequencing and microarray services, CD Genomics is dedicated to providing end-to-end genomics solutions for drug development, from target discovery to clinical trial testing. Additionally, we support and execute biomarker discovery and molecular diagnostic development.
Benefits of Genomics in the Drug Development Process
NGS is sensitive, accurate, inexpensive and informative, which can efficiently generate numerous data in a short time. The genomic data generated by NGS and microarray is informative in the whole drug development process including target discovery, target validation, preclinical development, and clinical development, especially the phase 4 effectiveness studies which may be required by formulary committees to establish the credibility, evaluation and replication of NGS-modulated drug assessments in target populations. Driven by these data, it is also possible to promote the development of personalized medicine.
Genomic Solutions for Drug Development
NGS can be applied at any stage of drug development. Early applications have focused on the oncology and infectious disease therapeutic areas, with emerging uses in biopharmaceutical development and vaccine production.
Genomic methods for drug development
WGS allows for detecting both coding and non-coding mutations associated with a specific disease, mitochondrial mutations, dosage abnormalities, and structural rearrangements.
WES targeting the coding regions is a cost-effective, sensitive technology, and the data interpretation is easier compared to WGS. It can identify both coding and mitochondrial mutations.
Targeted sequencing allows us to sequence a specific list of predetermined genes that are known to cause a specific phenotype. It is cost-effective and able to detect rare mutations.
Tumor sequencing and single-cell sequencing are able to detect rare somatic variants, tumor subclones, and circulating DNA fragments with increased sensitivity.
Mitochondrial DNA (mtDNA) sequencing can be used for comprehensive detection and analysis of mutations associated with mitochondrial disorders.
Microarray is a powerful tool for analyzing genetic variation efficiently on any scale. It is ideal for surveying thousands of samples at a time.