Genomics News

December 12, 2019

Researchers have discovered a possible explanation for why autoimmune disease are more common in females. The research, Published in the Proceedings of the National Academy of Sciences, USA, based on mouse models showed that the Double XX chromosome in females may be to blame.......

December 4, 2019

CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect and on-target complex mutations remain a concern, especially in view of future clinical applications. Non-human primates (NHPs) share close genetic and physiological similarities with humans, making them......

November 26, 2019

Sporadic Colorectal Cancer is one of the most common cancers worldwide with over 42,000 cases a year in the UK and a 57% survival rate over ten years. The exact causes of colorectal cancer are unknown, but gut microbiota were investigated as a potential link between diet, environmental stresses, and colon......

November 18, 2019

Over 100,000 people die each day from age-related causes and the mechanisms are poorly understood. The main factors implicated are cell death, DNA damage and DNA methylation. Whether these factors are part of development or due to our environment is up for debate.......

November 12, 2019

While genotyping studies are scavenging for suitable samples to analyze, large serum collections are currently left unused as they are assumed to provide insufficient amounts of DNA for array-based genotyping. Long-term stored serum is considered to be......

November 1, 2019

The flow chart of the hybrid sequencing workflow, including the experimental procedures (blue rectangles) comprised of PacBio sequencing and Illumina sequencing, and the computational components (pink rectangles) for Illumina-based PacBio error correction, followed by......

October 28, 2019

Currently the CRISPR Cas-9 system is the most widely used gene editing technique. It works by making double stranded DNA breaks, which can result in multiple insertions and deletions taking place; both near the cut site and at other DNA sequences which resemble the targeted gene. It is possible that these 'off target mutations'......

October 18, 2019

Manassas, VA – October 1, 2019 –ATCC launched its new ATCC Genome Portal, a publicly available database of reference-quality genome sequences matched to authenticated ATCC biological materials that will help researchers interpret and reproduce their results with confidence. The portal, which launched with an initial......

October 11, 2019

The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variety of experimental and computational pipelines for which best practices have not yet been established. Here, we use simulations based on five scRNA-seq library protocols in combination with nine realistic differential expression......

October 1, 2019

Tree peony (Paeonia section Moutan DC.) seeds are an excellent source of beneficial natural compounds that promote health, and they contain high levels of alpha-linolenic acid (ALA). In recent years, tree peony has been emerging as an oil crop. Therefore, combined analysis......

September 26, 2019

Although birds, mammals and fish have been successfully edited with CRISPR, reptiles have proved more challenging targets for the CRISPR/Cas-9 system due to the differences in their reproductive physiology. The brown anole lizard, Anolis sagrei......

September 17, 2019

We present a high-quality de novo genome assembly (rheMacS) of the Chinese rhesus macaque (Macaca mulatta) using long-read sequencing and multiplatform scaffolding approaches. Compared to the current Indian rhesus macaque reference genome (rheMac8), rheMacS......