Genomics News

September 12, 2019

To better understand the impact of chromatin structure on regulation of the prostate cancer transcriptome, we develop high-resolution chromatin interaction maps in normal and prostate cancer cells using in situ Hi-C. By combining the in situ Hi-C data with active and repressive histone marks, CTCF binding sites......

September 3, 2019

Back in 2009 the researchers discovered that those with a mutation in their DEC2 gene averaged 6.25 hours sleep per night, compared to 8.06 hours in those without the mutation. 10 years later, researchers have now discovered another mutation, ADRB1 gene, that allows members of a family......

August 26, 2019

Sequencing of DNA extracted from environmental samples can provide key insights into the biosynthetic potential of uncultured bacteria. However, the high complexity of soil metagenomes, which can contain thousands of bacterial species per gram of soil, imposes significant challenges......

August 21, 2019

Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisation......

August 12, 2019

Fruit flies share a significant proportion of their genes with humans, making them good models to study human diseases and ageing. As the fruit flies usually live for about two months their lifespan is easy to measure. Fruit Flies with a mutation known as E(z) were shown......

July 25, 2019

Darwin's bark spider (Caerostris darwini) produces giant orb webs from dragline silk that can be twice as tough as other silks, making it the toughest biological material. This extreme toughness comes from increased extensibility relative to other draglines. We show C. darwinidragline-producing major ampullate (MA)......

July 22, 2019

Researchers have discovered genome-wide variations in gene expression between male and female mammals. Although it has been known that different genes determine different characteristics in male and females, new research suggests that differences in gene expression has......

July 11, 2019

Nuclear DNA was first edited in the early 1970s, chloroplast DNA was first edited in 1988, and animal mitochondrial DNA was edited in 2008. However, no tool previously successfully edited plant mitochondrial DNA. Low mitochondrial diversity in plants......

July 2, 2019

Scientists studying stem cell differentiation usually only compare the differences in gene expression between the fully undifferentiated and differentiated cells. However, new research has revealed that the fleeting genetic changes during cell development could have......

June 26, 2019

Schematic of how SLAM-ITseq works. Cre is expressed in cells in which a cell type-specific promoter (Pcell) is activated and removes the floxed GFP-coding sequence followed by simian virus 40 polyadenylation sequence (SV40) between chicken β-actin promoter (CA) and UPRT-coding region......

June 16, 2019

A China-U.S. joint research team has engineered macaque monkeys to express a mutation linked to autism and other human neurodevelopmental disorders, through the genome-editing system CRISPR. These monkeys showed some behavioral traits and brain connectivity patterns......

June 4, 2019

DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine (6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and long-read PacBio sequencing have inherent limitations to detect DNA modifications. Here, using raw electric signals......