Genomics has changed how we understand biology. But often, the biggest challenge in cutting-edge research is simply not having enough high-quality DNA. Whether it’s from a single cell, tiny bits of DNA in blood (like from tumors), ancient specimens, or even crime scene evidence, getting enough genetic material without mistakes or missing pieces is critical. […]
In 1977, Frederick Sanger and his team invented the chain termination DNA sequencing technology, namely Sanger sequencing technology, which opened a door for human beings to explore the genetic code of life and won the Nobel Prize again. Since its inception, Sanger sequencing technology has experienced a series of important development stages. In the early […]
Sanger sequencing, a classic DNA sequencing technology, has played an irreplaceable role in molecular biology research, clinical diagnosis, genotyping, and other fields, thanks to its high accuracy and reliability, since its introduction in the 1970s. Although high-throughput sequencing technology has been widely used, Sanger sequencing is still the core technology in many laboratories and research […]
In the evolution of biotechnology applications, DNA extraction, a fundamental technology for analyzing genetic information, has consistently occupied a core and irreplaceable position. From the molecular verification of Mendel’s genetic factor hypothesis to the vast practice of the Human Genome Project, the acquisition of high-quality DNA constitutes the logical starting point for scientific discovery and […]
In the long exploration process of life science, the pursuit of the essence of genetic material has always been the core driving force for the development of the discipline. In the 19th century, Mendel discovered the laws of separation and free combination of genetic factors, starting with the pea hybridization experiment, which opened the scientific […]
Variant Calling Format (VCF) is a standardized text file format widely used in bioinformatics and genomics to store and exchange genetic variation information. Researchers and clinicians depend on this standardized approach when analyzing differences in DNA sequences across populations or individuals. The importance of this format extends across multiple domains of genetic research and personalized […]
Introduction Within cellular biology, chromosomes and chromatin function as essential vehicles for genetic material, fulfilling crucial functions during various phases of cellular existence. Chromatin represents the intricate association of DNA with proteins residing in the nuclear compartment, while chromosomes emerge as highly condensed formations when cells undergo division. These structures collaborate to maintain genomic integrity […]
What are Gene Fragments? Gene fragments refer to DNA segments synthesized through biochemical methods, typically comprising linear double-stranded DNA varying in length from several hundred to several thousand base pairs. These segments may contain exonic regions of genes or specific areas of the gene sequence. For instance, a cloned gene denotes a particular gene sequence […]
Gene fragment analysis is a transformative genetic analysis method that enables researchers to glean information on gene size, relative quantification, and genotyping through the separation and detection of fluorescently labeled DNA fragments. Its widespread adoption within the research community is attributed to its high sensitivity, resolution, and rapid turnaround. This technique plays an instrumental role […]
Sample Submission Guidelines