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The use of PD-1/PD-L1 inhibitors has significantly improved overall survival in a subset of non-small cell lung cancer (NSCLC) patients, but only about 20% of patients respond to treatment. Identifying predictors of response is crucial to improve patient selection for immunotherapy. However, current understanding of relevant predictors is limited by the lack of large, multi-omic […]
In the realm of molecular biology research, there exist two oft-confounded methodologies used with regularity: genotyping and DNA sequencing. Despite their seeming synonymy, these methods differ considerably regarding their impact on research outcomes and applications. This blog post endeavors to elucidate the contrasts between genotyping and DNA sequencing, while exploring their respective benefits and drawbacks. […]
Introduction to Ribosome Profiling Ribosome-profiling techniques were developed in response to the importance of measuring gene expression at the translational level. Ribosome profiling is a direct technique for determining the precise mRNA region read by the ribosome and for directly examining the transcripts associated with the translation machinery. Ribosome profiling is a cellular snapshot of […]
Introduction to Population Evolution A population, also known as a species, is a group of individuals who can all interbreed. The collection of these genes is known as a gene pool because these individuals can share genes and pass on combinations of genes to the next generation. Only populations, not individuals, go through the evolutionary […]
Introduction to SARS-COV-2 In December 2019, the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started and has enveloped the world in an unparalleled global pandemic. The clinical features of COVID-19 patients are comparable during the 2002-2003 outbreak of SARS-CoV-1, which caused more than 8,000 cases reported and about 800 deaths. As such, human SARS-CoV-2 […]
Genome-wide association study (GWAS) is a kind of method to detect all or most of the genes among different individuals in specific species and to understand the genetic variation between different individuals. Many susceptibility genes and loci have been found in colorectal cancer using the GWAS method, but there are still many unknown susceptibility genes […]
Jun 7, 2016, single cell transcription and methylation analysis have become the powerful tools for single cell research. However, it is difficult to reveal the direct correlation between DNA methylation and gene expression in single cells. This is because there is a large difference between the cells, and we can not detect a cell’s transcription […]
A common tumor suppressor gene was found in the patients with acute leukemia (AL). The finding reveals its synergistic effect between function abnormalities and a variety of different carcinogenic gene, providing an important foundation for research and development of novel leukemia treatment. Researchers found the transfer functional MLL – NRIP3 carcinogenic gene and SETD2 genetic […]
After Youyou Tu won the Nobel Prize in Physiology or Medicine, thousands of people focus on the chemistry prize. Who will take this honor? Early the morning of Wednesday, the Royal Swedish Academy of Sciences announced the 2015 Nobel Prize went for three scientists: Tomas Lindahl, Paul Modrich and Aziz Sancar. They won this prize […]
With the development of genetic technology, you are no stranger to transgenic animals. But here I’m not talking about the gene editing technology of human beings, I’m taking about the “gene editing” of nature. You may be confused because it seems like the word “ gene editing” is something patent of human beings. We are […]