CD Genomics Blog

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Plasmid Fact Sheet: Definition, Structure and Application

What is a plasmid? Plasmids are the small circular or linear double-stranded DNA molecules (ranging from a few to several hundred kilobases) found in bacterial cells but also present naturally in archeae and eukaryotes. The plasmids are not packaged inside a chromosome, and have no distinct 5’ or 3’ beginning or end. They can autonomously […]

Microbial Genomics Approaches to Promote Crop Yield

The importance of microbiology in crop yield Plants, bacteria, and fungi have coexisted in soil in a symbiosis for millions of years, and they both benefit greatly from symbiosis. Healthy microbial communities perform a variety of vital ecosystem functions, such as pathogen suppression and regulation of nutrient availability. For example, microorganisms make essential elements such […]

A Summary of Microbial Research in Animals

Why do we need to perform microbial research in animals? Enormous amounts of microorganisms live both within and on animal, the animal and its microorganisms exchange energy substances, transmit information to each other and form a holistic system. The impact of microorganisms on animal health is mainly reflected in mutual benefit sharing and symbiosis. If […]

Why Do We Perform 16S rRNA Sequencing

What is 16S rRNA? 16S ribosomal RNA (or 16S rRNA) is the component of the 30S small subunit of a prokaryotic ribosome, roughly 1500 base pairs. Figure 1A shows how 16S rRNA is involved in a prokaryotic ribosome. The bacterial 16S rRNA gene contains nine hypervariable regions (V1-V9) ranging from 30-100 base pairs, flanked by conserved regions (Figure 1C). You can find […]

18S rRNA and Its Use in Fungal Diversity Analysis

What is 18S rRNA? 18S ribosomal RNA (18S rRNA) is a component of the small eukaryotic ribosomal subunit (40S), and 40S and 60S constitute eukaryotic ribosomes. As a structural RNA for eukaryotic ribosomes, 18S rRNA, the homologue of 16S rRNA in prokaryotes and mitochondria, is thus one of the essential components of all eukaryotic cells. […]

Evolutionary Factors Have Stronger Influence on Gut Microbiome than Diet Patterns

As we all know that gut microbes provide multiple services to host, including digestion. Mammals with special diets, such as carnivores and anteaters, have special gut microorganisms to make it possible for them to eat such food. A common theme in the microbiome field is that the host diet has a significant impact on their […]

16S rRNA, One of the Most Important rRNAs

What is the 16S rRNA 16S rRNA (16S ribosomal RNA), is a component of the prokaryotic ribosome 30S subunit. The “S” in 16S is a sedimentation coefficient, that is, an index reflecting the downward velocity of the macromolecule in the centrifugal field. The higher the value, the greater the molecule. The 16S rRNA gene is […]

Everyone Has His Own Little “Universe”

Every day we are dealing with countless microbes. But the latest research on a metagenomics shows that the microbial population on our skin surface is highly stable. These little guys are wrapping around us, like an invisible “little universe”. The bacteria, fungi and viruses on our skin are mostly harmless, and even healthy. But there […]

Improving Metagenomic Sequencing Significantly by Using the TruSPADES Method

Researchers from St. Petersburg State University developed a method to improve the sequencing ability of DNA greatly, like life microbes in the human gastrointestinal tract or the ocean bacteria in a new study. This TruSPADES method assembles the short reads from the 300 base pairs of Illumina machine through computer into synthetic long reads. The […]

Metagenomics Class:Metagenomics And Related Research

  The concept of metagenome was proposed by Handelsman in 1998. It is the sum of DNA in a specific circumstance. Metagenomics is the research about the genome of micropopulation in the circumstance. It studies the microbial diversity, microbial population, evolutionary relationship, and its relationship with circumstance by structure functional gene screening and sequencing analysis. […]