CD Genomics is dedicated to producing high-quality ChIP-seq data sets to help you profiling DNA targets for histone modification, structural proteins, transcription factors, and other DNA-associated proteins at a genome-wide scale.
The Introduction of ChIP-Seq
ChIP-Seq (chromatin immunoprecipitation sequencing), which refers to the binding site analysis, is a way to analyze DNA-protein interactions. The technique combines chromatin immunoprecipitation (ChIP) with NGS to identify where the DNA binds to the associated proteins. It can be used to pinpoint the binding sites of any interested protein throughout the genome. ChIP-seq is often used to determine how transcription factors and other chromatin-related proteins affect phenotypic mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential to fully understand many biological processes and disease states. ChIP-Seq is a valuable tool for discerning and quantifying the specific DNA sequences where proteins bind or epigenetic modifications exist, it has played valuable roles in applications include studies on gene regulation, transcription complex assembly, DNA repair, histone modification, developmental mechanisms, disease progression and modifications.
Advantages of ChIP-Seq
A typical ChIP-Seq workflow is shown as follow:
| Sample requirements and preparation
| Bioinformatics Analysis
At CD Genomics, we provide you with high-quality sequencing and comprehensive bioinformatics analysis for your ChIP-Seq project, enabling accurately screen and determine the protein binding sites in the whole genome. If you have additional requirements or questions, please feel free to contact us.