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45-1 Ramsey Road, Shirley,
NY 11967, USA
Tel: 1-631-372-1052
Fax: 1-631-614-7828
Email:

Europe
Tel: 44-207-048-3343

Immune Repertoire Sequencing Services


Immune Repertoire Sequencing And Next Generation Sequencing Services

CD-Genomics provides Immune Repertoire Sequencing Service to amplify and sequence the immune repertoire with Next Generation Sequencing (NGS).

Immune repertoire is the sum total of functionally diverse T and B cells in a body at any given moment. Immune Repertoire Sequencing is to amplify the complimentary determining region (CDR) of B-cell receptor (BCR) or T-cell receptor (TCR) using multiple-PCR or 5' RACE methods, followed by high-throughput sequencing. Sequencing the expressed T- and B-cell receptor genes in the immune repertoire allows for an accurate evaluation of a person's health status and risks for different diseases.

T Cell Repertoire & B Cell Repertoire Sequencing (TCR & BCR)

BCRs and TCRs are similarly organized. Each receptor is composed of two distinct subunit chains (BCR: light chain and heavy chain, TCR: α chain and β chain). The antigen binding surface is formed by the variable region of each chain, which is encoded by recombined V, J, and D (BCR heavy and TCRβ) gene segments. (Jorg J.A. Calis et al. Trends in Immunology, 2014.12)

 

Our expert technicians will sequence your samples at our secure, state-of-the-art laboratory. They'll use our proprietary multiplex PCR with highly optimized primer sets and deep sequencing techniques that exclusively target T-cell and B-cell receptor genes. With the Immune Repertoire Sequencing Service the following panel are available:

 

Human

  • o   T-cell receptor alpha/beta (TCRα, TCRβ)
  • o   All TCR Chains
  • o   All BCR Chains
  • o   All TCR & BCR Chains

 

Mouse

  • o   All TCR Chains
  • o   All BCR Chains
  • o   All TCR & BCR Chains

 

CD Genomics basic data analysis includes:

  • • Basic data processing
  • • V, D, J, & C alignment to germline alleles
  • • Immune repertoire profiling
  • • Identification and comparison of clones present in given samples.

 

 

GenSeq TM Disease Susceptibility Panel
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CONTACT CD GENOMICS
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052
Fax: 1-631-614-7828
Email:

Europe
Tel: 44-207-048-3343

SERVICES
Sequencing
Microarray
Genotyping
Aptamers
Custom Libraries
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