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Illumina to Acquire Pacific Biosciences for $1.2B 1 NOV

Illumina adds Long-Read capabilities with $1.2B PacBio acquisition. And illumina said it expects to close the transaction in mid-2019.The companies said their deal will create a sequencing powerhouse that will combine Illumina’s short-read technologies with PacBio’s long-read sequencing capabilities more suitable for de novo sequencing and sequencing of highly homologous regions of genomes. The complementary offerings, Illumina and PacBio assert, will draw more researchers and clinicians as customers over time—and ensure that Illumina continues to dominate the sequencing market.......

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UK Is Expanding Their Genomes Project 3 OCT

The Secretary of State for Health and Social Care in the UK, the Rt Hon Matt Hancock MP, has announced plans for the NHS to sequence 5 million genomes over an unprecedented 5 year period. Moreover, the 100,000 Genomes Project, which is run by Genomics England (GeL), is to be expanded to incorporate the whole genome sequencing of 1 million patients. The announcement, which was made yesterday as part of the Secretary’s speech to the Conservative Party Conference, comes shortly after GeL revealed that more than 80,000 genomes have been sequenced as part of the project......

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Mitochondrial DNA Could Reduce the Signs of Ageing 1 AUG

Researchers have identified a method by which it is possible to reduce the signs of ageing, such as wrinkles and hair loss, in mice. The technique, which was discussed in a paper in Cell Death & Disease last month. As our cells age, the level of mitochondrial DNA (mDNA) starts to decline and this has previously been linked to several of the physical changes associated with growing older. To mimic this process, researchers worked with mice whose mDNA had been artificially depleted. In reaction to the change, the mice started to lose their fur and their skin became wrinkled.......

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Current Development of China Sequencing Market 31 JUL 

The DNA sequencing market in China is expected to reach 18.3B Yuan ($2.7B) by 2022, rising from 7.2B Yuan ($1.1B) last year at a much greater rate than the overall global market. The dramatic increase, which was predicted by CCID Consulting in Beijing, is the result of rising income within the country and greater investment into healthcare infrastructure. Current estimates value the global sequencing market at roughly $3B, but is expected to rise significantly over the next few years......

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A Novel Paediatric Whole Genome Sequencing (WGS) Workflow 27 JUL 

Researchers, led by scientists at University College London, have developed a novel paediatric whole genome sequencing (WGS) workflow that could run within the current National Health Service system. The workflow was outlined in a paper published in the Journal of Medical Genetics. Several teams in the United States have developed and implemented healthcare systems that enable the use of WGS when diagnosing critically ill infants that are suspected of having a genetic disease. However, the team behind this new work are arguing that previous work in this area has been centred......

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A New Study Has Managed To Uncover The Centromere of The Y Chromosome. 13 APR 

In an effort to solve this genetic cypher, the Human Genome Project, a collaborative international consortium, was created. The goal was to read out the DNA sequence – made up of four letters, or bases, A,T,G and C – of all human genes (genome). In 2003, a near-complete map of the human genome was reported. Yet, the assembled genome represented only 92% of all human genes. Gaps remained that could not be easily decrypted. For many researchers, that elusive 8% of the genome is a holy grail.The unmappable genome is associated with......

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A New Important Function of RNA Modification in Human Cells Is Uncovered 9 APR

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.Now, a research team has uncovered a completely new mechanism that controls how proteins are produced to direct stem cell function. Dr. Bellodi’s laboratory uncovered a new important function of pseudouridine, the most common type of RNA modification in human cells......

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A 3D-Printed, Low-Cost Droplet Microfluidic Control Instrument for Single-Cell Analysis February 26/2018

February 26, 2018 Scientists at the New York Genome Center (NYGC) and New York University (NYU) say they have begun to facilitate broad access to single-cell sequencing by developing a 3D-printed, po......

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NmeCas9 Can Perform CRISPR Cutting on Both RNA And DNA February 21/2018

February 21, 2018 CRISPR-Cas9 works through the combined action of the Cas9 protein, which cuts DNA, and a short guiding RNA (sgRNA), which tells Cas9 where to make the cut. Together, these two molec......

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DNAnexus’New Solution: Streamlines the Use of NGS Data in Clinical Trials February 16/2018

February 16, 2018 Gene therapy is an emerging strategy to treat diseases caused by genetic abnormalities. One form of gene therapy involves the direct repair of a defective gene, using genome-editing......

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