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Microecology and Pharma


Microecology and Pharma

The importance of microbial genomics in the medical field

The study of microbial genomes enables us to better understand the biology of bacteria, fungi, viruses, and their interaction with the environment. Microbial genomics involves the high-throughput sequencing process and comprehensive bioinformatics analysis that determine microbial species, community structure, and biological function. It ensures a safe and supervised drug production process and enables researchers to understand the interaction between the microorganisms and the environment, hence grasping the pathogenic mechanism and probably developing new vaccines and drugs for human diseases.

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Accelerate research and practice in pharma

We provide the next-generation sequencing technology, third-generation sequencing, gene chip analysis, SNP genotyping, and real-time qPCR technologies to determinate which microorganisms are present in the sample and their quantity, and study the diversity of microorganism and the relationship between the human microbiome and human health. Additionally, we also help you conduct routine monitoring for control of manufacturing processes. Our microbial genomics services are dedicated to supporting a drug’s journey from discovery to market.

The main research directions:

  • Drug target discovery: explore the relationship between clinical microbes and infectious diseases or various non-infectious diseases such as obesity, asthma, or diabetes.
  • Microbial therapeutics: develop new vaccines and drugs for the prevention and treatment of microbial infections and other diseases.
  • Biomarker discovery: discover and elucidate microbial and functional biomarkers in the human microbiota and other microbiomes.

What can we do?

  1. 1. Identify microorganisms and microbial biomarkers that affect specific disease states.
  2. 2. Recognize and identify different microorganisms which closely related to human health.
  3. 3. Find valuable biomarkers and drug target for drug research and development.

Note: Our services are for research use only, not for disease diagnosis and treatment.

Detectable Objects

We have detected a variety of human microbiome samples and environmental monitoring samples in pharmaceutical facility.

Detectable Microorganisms

Bacteria, fungi, viruses, etc.

Detection Methods

The next-generation sequencing, third-generation sequencing, gene chip analysis, SNP genotyping, real-time qPCR, etc.

Technical Platforms

We are equipped with Illumina Hiseq/Miseq, Ion PGM, PacBio SMRT systems, Nanopore systems, PCR-DGGE (PCR-denaturing gradient gel electrophoresis), real-time qPCR, Clone library, and other detection platforms.

Sample Requirement

  • DNA sample: total DNA ≥ 300 ng, concentration ≥ 10 ng/μL, OD260/280=1.8-2.0
    Make sure the DNA is not degraded and do not freeze and thaw the DNA repeatedly.
    Please prepare enough ice pack or dry ice to ensure low temperature during transportation.
    We provide a broad range of oral and fecal sample collection kits for microbial recovery and analysis.

Workflow

High-throughput sequencing analysis process Figure 1. High-throughput sequencing analysis process

PCR-DGGE analysis process Figure 2. PCR-DGGE analysis process

Bioinformatics Analysis

Basic Analysis Routine Analysis (According to Customer Requirements) Advanced Data Analysis
Sequence Filtering and Trimming Heatmap Phylogenetic Tree
Sequence Length Distribution VENN LDA-Effect Size (LEfSe)
OTU Clustering and Species Annotation Principal Components Analysis (PCA) Network Analysis
Diversity Index Microbial Community Structure Analysis Correlation Analysis
Shannon-Wiener Curve α Diversity Index Analysis
Rank-Abundance Curve Matastats Analysis
Rarefraction Curve Weighted Unifrac test
Multiple Contrast CCA/RDA Analysis
Heatmap
Principal Components Analysis (PCA)
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