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Microbial Therapeutics

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Microbial Therapeutics: New Opportunities for Medicine

Microbial Therapeutics

Microbes was considered human’s enemies due to their ability to cause disease. However, it is now clear that they are good at synthesizing biologically active molecules and even used as therapeutics. Indeed, more and more pharmaceutical companies are now taking microbial therapeutics as the lead in clinical development. The potential of microbial therapeutics is evident in the probiotics and live bacterial prophylactic vaccines, as well as more recent cases that using fecal microbiota transplant to improve human health or cure certain diseases. Besides, microorganisms can be engineered to act as living therapeutics designed to perform specific functions in the human body, such as the prevention of infections, elimination of tumors, and treatment of metabolic disorders. Engineered living systems are considered as the next generation of therapeutics. The production and delivery of therapeutic drugs by microbes has several advantages over traditional systems: decreased production costs, side effects, and dosage requirements.

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Our Solution for Microbial Therapeutics

The microbiome has progressively become an attractive target for potential therapeutics. However, one of the biggest difficulties is to determine cause-effect relationships and to design microbial therapeutics for these conditions. We are dedicated to offering a full list of microbial genomics services to accelerate the development of microbial therapeutics, including microbial whole genome sequencing, 16S/18S/ITS sequencing, metagenomics, metatranscriptomics, microbial epigenomics, prokaryotic RNA sequencing, as well as microbial ID and AMR profiling.

Main Research Directions

  • Reveal the relationship between microbes and human disease.
  • Development of engineered microbes to cure certain human diseases.
  • Microbiome-based therapies to alter the microbial composition of human body, like the fecal microbiota transplant.

What Can We Do?

  1. 1. Microbial diversity analysis of the human microbiome on the skin, or in the gut.
  2. 2. Metabolomic pathway characterization of the microbial ecosystem.
  3. 3. Comprehensive bioinformatics analysis to define functional signatures for disease states.
  4. 4. Testing and validation of engineered microorganisms.
  5. 5. Microbiological Quality Control (QC) in the Pharmaceutical Industry.

Note: Our service is for research use only, not for disease diagnosis or treatment.

Detectable Objects

Bacteria, archeae, fungi, protozoan, viruses.

Detection Methods

Next-generation sequencing (NGS), long-read sequencing, quantitative PCR (qPCR), and other molecular biology techniques.

Detection Platforms

Illumina HiSeq/MiSeq, Nanopore systems, PacBio RSII, PacBio Sequel, Applied Biosystems real-time PCR platforms, et al.

Sample Requirement

    1. DNA sample: 1.8 < OD260/280 < 2.0 (without degradation or contamination)
    2. RNA sample: RIN ≥ 7.0, 28s/18s ≥ 1.5 (without degradation or contamination)

Workflow

The high-throughput sequencing analysis processFigure 1. The high-throughput sequencing analysis process.

Bioinformatics Analysis

Our bioinformatics analysis pipeline is flexible to your needs.

Taxonomic Assignment Species annotation
Rarefaction Curve
Shann-Wiener Curve
Rank Abundance Curve
Statistical Analysis Heatmap
VENN
Principal Components Analysis (PCA)
Comparative Analysis RDA/CCA
PCA/PCoA
Network Analysis
Functional analysis BLASTX, KEGG, eggNOG, CAZy, CARD, ARDB etc.
PICRUSt
TAX4Fun
Phylogenetic Analysis (Un)Weighted Unifrac
Phylogenetic Trees

References

  1. Mimee M, Citorik R J, Lu T K. Microbiome therapeutics—advances and challenges. Advanced drug delivery reviews, 2016, 105: 44-54.
  2. Pedrolli, et al. Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox. Trends in Biotechnology, 2018, doi:10.1016/j.tibtech.2018.09.005.

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