The commensal microbes associated with humans or animals contribute to the host health as they play a vital role in shaping host immunity and preventing infectious disease. Given the widespread presence of antimicrobial resistance, promoting healthy microbiota in humans and animals became a global issue. Biomarker discovery has proven to be one of the most powerful and broadly applicable approach to translate molecular and genomic data into practice. However, the bacterial genome is highly dynamic even within strains of the same genus. Therefore, the identification of useful biomarkers in mixed microbial communities is very challenging. High-resolution techniques such as next-generation sequencing (NGS) and long-read sequencing are necessary for effective microbial biomarker discovery. Genomic methods can also be used to systematically discover potential biomarker genes through deep sequencing, literature-based data mining, and comparative genomics.
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We are dedicated to providing the highest-quality microbial genomics services to help you investigate microbe-microbe and host-microbe interactions within the human/animal microbial communities. We utilize next-generation sequencing (NGS) and long-read sequencing technologies to characterize microbial communities. We provide (full-length) 16S/18S/ITS sequencing and metagenomics for rapid detection of bacteria, archaea, fungi, and viruses, and a more comprehensive combination of microbial genomics services for further characterization of microbes, genes, or pathways of interest.
Note: Our service is for research use only, not for disease diagnosis or treatment.
Bacteria, fungi, protozoan, viruses.
Next-generation sequencing (NGS), long-read sequencing, quantitative PCR (qPCR), and other molecular biology techniques.
Illumina HiSeq/MiSeq, Nanopore MinIONTM, PacBio RSII, PacBio Sequel, Applied Biosystems real-time PCR platforms, et al.
Figure 1. The high-throughput sequencing analysis process.
Our bioinformatics analysis pipeline is flexible to your needs.
| Taxonomic Assignment | Species annotation |
| Rarefaction Curve | |
| Shann-Wiener Curve | |
| Rank Abundance Curve | |
| Statistical Analysis | Heatmap |
| VENN | |
| Principal Components Analysis (PCA) | |
| Comparative Analysis | RDA/CCA |
| PCA/PCoA | |
| LEfSe | |
| Network Analysis | |
| Functional analysis | BLASTX, KEGG, eggNOG, CAZy, CARD, ARDB etc. |
| PICRUSt | |
| TAX4Fun | |
| Phylogenetic Analysis | (Un)Weighted Unifrac |
| Phylogenetic Trees |
References
Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.
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