Mycobacterium tuberculosis ARGs Analysis

Our DNA microarray-based platform can rapidly and simultaneously detect multiple resistance-related genes and can detect multiple mutation sites of these resistance genes. The study found that Mycobacterium tuberculosis was mainly resistant to antibiotics such as rifampicin, isoniazid, and streptomycin. The services we can provide to customers include but are not limited to the following.

• Rifamycin resistance gene detection: Rifampicin (RFP), rifapentine (RFT) and rifabutin (RFB) are all first-line anti-TB drugs. Our detection service can target the mutation of rpoA, rpoB, and rpoC.
• Isoniazid and isonicotinic acid derivative resistance gene detection: Our detection service can target the deletion or mutation of katG, inhA, and ethA.
• Ethambutol resistance gene detection: Our service targets overexpression or mutation of the arabinosyltransferase encoding genes embA, embB, and embC.
• Pyrazinamide resistant genes detection: Our service can target mutations in the pyrazinamide-encoding gene pncA, ribosomal protein S1-encoding gene rpsA, and aspartate decarboxylase gene panD.
• Streptomycin resistance gene detection: Our service can target the mutations of ribosomal protein S12 coding gene rpsL and 16S rRNA coding gene rrs. Focus on mutations in RpsL43 and 88 codons and rrs905 and 513 nucleotides.
• Quinolones resistance gene detection: Our service can target mutations in the A subunit encoding gene gyrA or the B subunit encoding gene gyrB.
• Kanamycin, capreomycin, and viomycin resistance gene detection: Our service can target mutations in the rrs and mutations in tlyA.
• Macrolide resistance genetic detection: Our service can target mutations in ermMT and Tap.
• Cycloserine resistance gene detection: Our service can target mutations in the genes gadA, alrA, ddlA, and ald.