Mycobacterium tuberculosis ARGs Analysis

Our DNA microarray-based platform can rapidly and simultaneously detect multiple resistance-related genes and identify various mutation sites associated with drug resistance. The study found that Mycobacterium tuberculosis was primarily resistant to antibiotics such as RIF-class agents, isonicotinic acid derivatives, and aminocyclitol-based compounds. The services we offer include but are not limited to the following:

• Rifamycin resistance gene detection: RIF-class agents—including RFP, RFT, and RFB—are key first-line anti-TB drugs. Our detection service targets mutations in rpoA, rpoB, and rpoC.
• Isonicotinic acid derivative resistance gene detection: Our service identifies deletions or mutations in katG, inhA, and ethA, which are associated with resistance to this class of agents.
• Arabinofuranosyl transferase-targeting drug resistance gene detection: Our platform detects overexpression or mutation in embA, embB, and embC, which are linked to resistance against ethambutol-type compounds.
• Pyrazinecarboxamide derivative resistance gene detection: We detect mutations in pncA, rpsA, and panD, genes related to resistance against PZA-class agents.
• Aminocyclitol-based agent resistance gene detection: Mutations in rpsL and rrs are assessed, especially at codons 43 and 88 of RpsL, and nucleotide positions 905 and 513 of rrs.
• Quinolone resistance gene detection: Our service targets mutations in the gyrA (A subunit) and gyrB (B subunit) genes.
• Second-line injectable agent resistance gene detection: This includes resistance to AG-class agents such as kanamycin analogs, and cyclic peptide-based agents like capreomycin-type and viomycin-type compounds. Mutations in rrs and tlyA are key markers.
• Macrolide resistance gene detection: Our detection targets mutations in ermMT and Tap.
• Cyclic amino acid derivative resistance gene detection: Resistance associated with cycloserine-type agents is detected by analyzing mutations in gadA, alrA, ddlA, and ald.