Over the past years, widespread antibiotic resistance has attracted much attention since it became an important threat to modern medicine. Efforts to develop new antibiotics with novel drug targets are prioritized. Microbial genomics is a promising method to discover drug targets. Coupled with powerful bioinformatics tools, microbial genomics enables the identification, detection, selection, and validation of novel antibacterial pathways to accelerate the drug discovery process. Information on the bacterial genome sequences, DNA methylation, and gene or protein expression levels on a genome-wide scale are produced. Comparative genomic methods can identify highly conserved genes within and between bacterial species, making them attractive drug targets for the development of new antibiotics.
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According to your specific needs, we employ various sequencing platforms, including Illumina Miseq/Hiseq, Roche 454, PacBio Sequel, and Nanopore MinION systems, to gain huge and accurate microbial genomic data. We provide comprehensive information about genomic sequence and annotation of bacterial and archaeal genomes, and perform comparative genomics and evolutionary studies to find out the key genes that participate in key bacterial processes using tools such as the TIGR Comprehensive Microbial Resource (CMR) and OrthoMCL standalone software.
Note: Our service are for research use only, not for disease diagnosis or treatment.
Bacteria, fungi, archaebacteria, mycoplasma.
Next-generation sequencing (NGS), long-read sequencing, PCR denaturing gradient gel analysis (PCR-DGGE), real-time qPCR.
Illumina HiSeq/MiSeq, Ion PGM, PacBio SMRT systems, Nanopore systems, PCR-DGGE, Real-time qPCR, clone library etc.
Figure 1. High-throughput sequencing analysis process.
Figure 2. PCR-DGGE analysis process.
| Analysis Content | Details |
| Strain diversity analysis | Understand the emergence of drug-resistant strains |
| Microbial phylogenetics | Study of epidemiology and links between genetic diversity and emergence of drug resistance |
| Comparative pathway analysis | Identification of major pathways using databases like BioCyc and KEGG |
| Comparative genomics | Identification and prioritization of essential drug targets using databases like the Database of Essential Genes and the database of Online Gene Essentiality |
References
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