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Antibiotic Resistance Genes Screening


Antibiotic resistance is one of the crucial concerns emerging in global health care. Antibiotic-resistance bacteria can acquire antibiotic resistance genes (ARGs) due to selective pressure. We are dedicated to offering efficient, accurate, genome-based analysis of antibiotic resistance gene screening services, to locate ARGs, identify novel ARGs, and reveal the molecular mechanism underlying ARGs transfer.

Our Advantages:
  • Whole-genome sequencing and powerful bioinformatics analysis
  • Multiple samples can be sequenced at a time with a streamlined workflow suitable for automation.
  • State-of-the-art sequencing platforms are available like Illumina HiSeq/MiSeq, Nanopore MinION, and PacBio Sequel.
  • Delivery of robust sequencing and data analysis results.
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Introduction to our antibiotic resistance genes screening platform

One emerging issue with antibiotics is the development of antimicrobial resistance (AMR), and many efforts have been devoted to elucidating the molecular mechanisms of antibiotic resistance. However, the screening of microorganisms for antibiotic resistance using traditional methods can be very laborious and time-consuming. CD Genomics allows fast and efficient screening of antibiotic resistance genes based on whole-genome sequencing (WGS) and bioinformatics analysis. We can determine which ARGs are present in your microbial strains, discovery novel ARGs, identify mobile genetic elements that probably promote the transfer of ARGs to other microorganisms, and assess the safety of your bacterial strains.

There are currently more than 1,000 types of ARGs that have been identified to be responsible for resistance to hundreds of antibiotics. Knowledge of antibiotic resistance genes helps us understand how antibiotics work and how bacteria fight them. Our antibiotic resistance genes screening platform can be helpful in many antimicrobial applications such as diagnostic tests, new antibiotics development, the management and modification of existing antibiotics, and revealing the factors that promote the emergence and resistance of pathogenic microbes.

Project Workflow

Bioinformatics Analysis

We have a standard bioinformatics pipeline for antibiotic resistance genes screening, however, we can also customize the bioinformatics pipeline to your needs.

Pipeline Details
Sequence alignment Raw data filtering and trimming, sequencing coverage, sequence alignment, and genome assembly
Genome annotation Open reading frames (ORFs) annotation and comparative gene clusters analysis using tools like RAST
ARGs detection Reveal distribution and localization of ARGs, discover novel ARGs; visualization of ARGs
Comparative genomics Reveal molecular mechanisms of the evolution of resistant strains

Sample Requirement

Sampling kits: We provide a range of microbial sampling kits for clients, including MicroCollect™ oral sample microbial collection products and MicroCollect™ stool sample collection products.

Deliverables: Raw sequencing data (FASTQ), quality-control dashboard, visualization of ARGs, and your designated analysis report.

Reference

  1. Abdelgader S A, Shi D, Chen M, et al. Antibiotics Resistance Genes Screening and Comparative Genomics Analysis of Commensal Escherichia coli Isolated from Poultry Farms between China and Sudan. BioMed research international, 2018, 2018.

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