The microbiome found in the mouth is highly complex with more than 700 species, including viruses, fungi, bacteria, archaea, and protozoa, some of which are primarily disease-associated. Under normal conditions, the interaction between oral microbiome, and between microbiome and host maintains a dynamic balance, but oral homeostasis is easily disturbed by external factors. The ecological imbalance of oral microorganisms can not only induce a variety of oral diseases (such as caries, periapical disease of dental pulp, periodontal disease, etc.), but are also closely related to tumor, diabetes, rheumatoid arthritis, cardiovascular disease, premature delivery and other systemic diseases, which have a great impact on human health.Request a Quote
We are equipped with Illumina Hiseq/Miseq, Ion PGM, PacBio RSII, and Nanopore MinION platforms to help you identify the microorganisms presented in the oral cavity, and analyze the diversity, abundance, evolutionary relationship, and disease implications of the oral microbiome. Besides, we also provide qualitative and quantitative studies of the oral microbiome using real-time qPCR.
Note: Our service is for research use only, and not for therapeutic or diagnostic use.
DNA samples of oral microbiome from humans and animals (such as mouse rat, sheep, monkey, horse, fish, etc.) can be tested.
Viruses, fungi, bacteria, archaea, etc.
We are equipped with Illumina HiSeq/MiSeq, Ion PGM, PacBio SMRT systems, Nanopore systems, PCR-DGGE (PCR-denaturing gradient gel electrophoresis), real-time qPCR, clone library, and other detection platforms.
Figure 1. High throughput sequencing analysis process
Figure 2. PCR-DGGE analysis process
|OTU Clustering||Distribution-Based OTU-Calling|
|Rank Abundance Curve|
|Principal Components Analysis (PCA)|
|Functional analysis||BLASTX, KEGG, eggNOG, CAZy, CARD, ARDB etc.|
|Phylogenetic Analysis||(Un)Weighted Unifrac|