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Solid Tumor Panel Sequencing (500 genes)

Solid Tumor Panel Sequencing (500 genes)

Introduction

The Gene Panel is a new assay utilizing next generation sequencing (NGS) technology that allows for comprehensive genomic analysis of solid tumor samples. Because of the rigorously designed capture or amplicon sequencing strategy, Gene Panel makes NGS and data analysis more economical, flexible and efficient.

CD Genomics utilizes targeted genome sequencing to provide more efficient and accurate targeting of specific genes or mutations, and even detect low frequency variants in cancer-associated genes. Targeted genome sequencing facilitates the sequencing of a large number of genes and samples in a single, cost-effective assay.

We use capture-based next generation sequencing (Illumina platform) to target and analyze over 500 known tumor genes designed to detect variants and assess tumor mutational burden (TMB) and microsatellite instability (MSI) in tumor samples, allowing for the discovery of multiple positive tumor markers and novel drug targets at once. Our solid tumor panel sequencing service can be used to detect formalin-fixed, paraffin-embedded (FFPE) tissues such as lung cancer, melanoma cancer, ovarian cancer, and gastric cancer, etc. We also provide custom bioinformatics analysis services for you to perform targeted tumor gene analysis and comparative tumor tissue analysis in a short time, etc.

Highlights of Our Solid Tumor Panel Sequencing Service

We Can Help You With

Gene List of Solid Tumor Panel (500 genes)

ABL1 ABL2 ACVR1 ACVR1B AKT1 AKT2 AKT3 ALK ALOX12B ANKRD11
ANKRD26 APC AR ARAF ARFRP1 ARID1A ARID1B ARID2 ARID5B ASXL1
ASXL2 ATM ATR ATRX AURKA AURKB AXIN1 AXIN2 AXL B2M
BAP1 BARD1 BBC3 BCL10 BCL2 BCL2L1 BCL2L11 BCL2L2 BCL6 BCOR
BCORL1 BCR BIRC3 BLM BMPR1A BRAF BRCA1 BRCA2 BRD4 BRIP1
BTG1 BTK C11orf30 CALR CARD11 CASP8 CBFB CBL CCND1 CCND2

(Check the Gene List of Solid Tumor Panel (500 genes) for more genes.)

Service Specifications

Service Specifications

Sample Requirements

  • Sample types: genomic DNA, formalin-fixed paraffin-embedded (FFPE) tissues
  • Recommended amount: 2 μg
  • Minimum amount: 40 ng DNA, 40 ng RNA

Collection: DNA samples (stored in TE buffer or equivalent), FFPE samples (recommended cryopreservation). Please make sure that the DNA is not degraded.

Service Specifications

Sequencing

  • Illumina PE150
  • Enrichment Method: Hybrid-capture enrichment
  • More than 80% of bases with a ≥ Q30 quality score
  • Recommended sequencing depth: ≥ 1000x
Service Specifications

Bioinformatics Analysis

  • Turnaround time: within 6 weeks
  • Primary analysis: read alignment, SNP/Indel/CNV annotation
  • Secondary analysis: statistical and pathway analysis, NMF mutation characterization, driver gene prediction
  • Tertiary analysis: susceptibility gene screening, variants analysis, structure analysis
  • Custom bioinformatics analysis

Solid Tumor Panel Workflow

CD Genomics concentrates on disease genomics and our rapid NGS workflow, which maximize efficient and cost effective solid tumor panel sequencing services and bioinformatics support for our clients.

Gene Panel Workflow

* For Research Use Only. Not for use in diagnostic procedures.

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