CDCap™ Solid Tumor Fusion RNA Panel Kit

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Overview

Product Description

The CDCap™ Solid Tumor Fusion RNA Panel interrogates 105 genes most commonly associated with clinically significant fusions in solid tumor research. The panel covers all transcript coding regions and select UTR regions implicated in fusion events as officially included in RefSeq 109. With CDCap Technology, this solution enables comprehensive enrichment of RNA-level fusion, mutation, and gene expression data for confident molecular profiling.

Features

Key Features & Advantages

Novel Fusion Discovery
· Identify novel fusion gene partners or analyze complex structural rearrangements with high confidence.
Optimized Fusion Sensitivity
· Exclusion of intronic sequences from mRNA targets improves fusion analysis breadth and sensitivity.
Cost-Effective, Streamlined Workflow
· Targeted enrichment of fusion-critical genes eliminates ribosomal RNA removal steps during RNA library preparation, reducing costs while enhancing detection sensitivity.
Clinically Actionable Insights
· RNA-level fusion data delivers direct clinical relevance to for confident molecular profiling.

Specifications

Product Specifications

Enrichment Method:	Probe Hybridization Capture
Species:	Human
Variant Types:	SNV、Indel、Fusion、Gene Expression
Target Size:	700Kb
Cancer Type:	Pan-Cancer
Number of Genes:	105
Sample Type:	Tissue、FFPE
Input DNA/RNA:	>30ng
Method:	NGS
Sequencing Platform:	Illumina
Storage:	Store at -20 °C.

Data

1. Excellent Capture Performance

Figure 1. Capture performance of CDCap™ Solid Tumor Fusion RNA Panel.
A. Typical capture sequencing data; B. Comparison of the relative abundance of target genes between capture sequencing and RNAseq.

2. Fusion Detection Performance

Figure 2. Fusion detection of FFPE fusion RNA standards by CDCap™ Solid Tumor Fusion RNA Panel
A. Comparison of OncoFu E targeted enrichment and RNAseq; B. Targeted enrichment performance of OncoFu E after multiple dilution of the standards.

Gene List

ABL1*†	ABL2	AKT3	ALK	ARHGAP26	AXL	BCL2†	BCOR*	BRAF	BRD3*	BRD4*	CAMTA1
CCNB3*	CCND1	CIC†	COL6A3	CSF1R	DNAJB1	EGFR	EML4	EPC1*	ERBB2†	ERG*	ESR1
ETS1	ETV1*	ETV4	ETV5*	ETV6*	EWSR1	FGFR1	FGFR2	FGFR3	FGR*	FLI1	FLT3
FOSB	FOXO1	FUS	GLI1	HMGA2	INSR	JAK2*	JAK3	JAZF1	KIF5B†	KIT†	KMT2A
MAML2	MAST1	MAST2	MEAF6	MET*	MLLT3	MSH2	MSMB†	MUSK	MYB	MYC	NCOA1*
NCOA2*	NOTCH1	NOTCH2	NOTCH3†	NR4A3*	NRG1	NTRK1	NTRK2	NTRK3	NUMBL	NUTM1	PAX3
PAX7	PDGFB	PDGFRA	PDGFRB†	PHF1*	PIK3CA*	PKN1	PLAG1*	PPARG*	PRKACA	PRKCA	PRKCB
RAF1	RARA*	RELA	RET	ROS1	RSPO2*	RSPO3	SS18	STAT6*	TAF15	TCF12†	TCF3
TERT	TFE3	TFEB	TFG	THADA	TMPRSS2*†	TP53*	USP6*	YWHAE*