Drug Safety for Children

Description

Personalized medicine is particularly important for disease treatment whereby many clinically used drugs exhibit a large interindividual pharmacokinetic and pharmacodynamic variability. This variability can lead to therapeutic failure or severe toxicity. Understanding of how genetic variations influence drug disposition and action could help in disease therapy based on individual’s genetic makeup. Pharmacogenomics is the study of how variations in the human genome affect the response to medications.

Pharmacogenomics is the study of how variations in the human genome affect the response to medications.
CD Genomics provides a predesigned panel, which covers 137 pharmacogenomics related genes for children. Utilizing amplicon sequencing technology by illumina system can provide more efficient and accurate targeting for the 137 genes and mutations. This panel can help to guide for selecting appropriate drugs and dosage for individual patients, for achieving personalized medication. If necessary, you can choose genes that fit your requirements.

Diseases associated with the 137 genes, including psychiatry, neurology, rheumatology, immunology, cardiovascular, oncology, pain, infection, respiratory, gastroenterology, endocrinology, hematology.

Gene List of Drug Safety for Children Panel

ABCB1 ABCC4 ABCG2 ACE AD0RA2A ADCY9 ADD1 ADRA2A ADRB1 ADRB2
AGT AGTP1 ANKK1 APOA5 APOE ATIC BCHE C11orf65 CALU CBR3
CCHCR1 CDA CDK4 CEP72 CES1 CETP CFTR CHIA CHRNA3 CNR1
COMT COQ2 CREB1 CRHR1 CYP1A2 CYP1B1 CYP2B6 CYP2C19 CYP2C8 CYP2C9
CYP2D6 CYP3A4 CYP3A5 CYP4F2 DPP6 DRD1 DRD2 DRD3 DYNC2H1 EPHX1
EPM2A ERCC1 ESR1 F2 F5 FAAH FCER2 FCGR2A FCGR3A FDPS

(check the Drug Safety for Children Panel Gene List for more genes)

Highlights of Drug Safety for Children Panel Sequencing Service

  • Target-enrichment sequencing by Illumina provides ultra-deep sequencing to target specific genomic regions with lower costs.
  • High coverage uniformity ensures the sequencing data more efficiency.
  • SNVs, indels can be detected.
  • Strict quality control throughout the pipeline workflow to ensure the accuracy and repeatability of the sequencing.
  • Fast turnaround time.

Applications of Drug Safety for Children Panel Sequencing

  • Precise medication guidelines
  • Pharmacogenomics

Service Specifications

Service Specifications

Sample Requirements

  • Sample types for genome DNA from buccal swabs, blood.
  • Recommended amount: 2μg
  • Minimum amount: 1μg
  • Collection: DNA samples are stored in TE buffer or equivalent. Buccal swabs are collected by routine buccal swab collection.
Service Specifications

Sequencing

  • Illumina PE150
  • Enrichment Method: Amplicon sequencing
  • More than 80% of bases with a ≥ Q30 quality score
  • Recommended sequencing depth: ≥ 500x
Service Specifications

Bioinformatics Analysis

We provide customized bioinformatics analysis including:

  • Read alignment
  • Variant calling/Annotation

Gene Panel Workflow

CD Genomics provides the accurate and cost-effective pharmacogenomics sequencing and bioinformatics analysis. Our professional expert team executes quality management, following every procedure to ensure confident and unbiased results. The general workflow for pharmacogenomics sequencing is outlined below.

Gene Panel Workflow

For more information about the pharmacogenomics testing or need other amplification requirements, please contact us.

References:

  1. Jing L, et al. Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy. Pharmacogenomics and Personalized Medicine, 2011. 4, 11-33.
  2. Sarah R, et al. Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management. Pharmacogenomics and Personalized Medicine, 2010. 3, 129-143.
* For Research Use Only. Not for use in diagnostic procedures.

Online Inquiry
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  • 45-1 Ramsey Road, Shirley, NY 11967, USA
  • 1-631-275-3058 (USA)
           44-208-144-6005 (Europe)
  • 1-631-614-7828
  • info@cd-genomics.com
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