Cancer NGS panels typically target specific regions of the genome known to be associated with cancer-related genes and mutations, to study various aspects of cancer biology, including tumor profiling, identification of genetic mutations, assessment of treatment response, and exploration of potential therapeutic targets.
Our custom Cancer NGS Panels offer several library preparation, sequencing, and data analysis options for cancer research. Streamlined library prep workflows and flexible kit configurations accommodate multiple study designs.
Based on our CDCAP® and CDAMP® Target Enrichment platforms, CD Genomics offers a custom Cancer NGS Panel to evaluate DNA, RNA and entire CDS regions of over 400 genes, as well as rearranged regions in various somatic cancer-associated genes.
Enable the identification of somatic mutations, copy number alterations, and other genetic variations specific to solid tumors. Analyze these panels to understand the genetic landscape of different solid tumor types and identify potential therapeutic targets. Learn more about our Custom Solid Tumor Panels Service.
Focus on genes and regions relevant to hematological malignancies, such as leukemia, lymphoma, and myeloma. By sequencing genes associated with these diseases, you can identify specific mutations, fusion genes, and other genomic alterations that contribute to hematological cancers.
Designed to include genes and regions associated with germline mutations that increase the risk of developing various types of cancer. You can identify hereditary mutations and provide genetic counseling to individuals and families at increased risk. Germline testing with custom panels can guide personalized cancer risk assessment and management strategies. Refer to our Oncorisk Panel.
Our Pancancer Panels allow to study shared molecular features and identify common pathways and genetic alterations across different cancers. Refer to our Pan-cancer Panels for more details on how to facilitate the discovery of potential therapeutic targets that may be applicable to multiple cancer types.
Include genes associated with the immune system and immunotherapy response. Analyze these panels to investigate the interaction between tumors and the immune system, identify immune-related genetic alterations, and assess the efficacy of immunotherapies. Custom panels tailored for immuno-oncology research can aid in understanding the mechanisms of immune evasion and developing personalized immunotherapeutic approaches. Our Immune-oncology Panel investigates over 300 genes involved in tumor-immune system interactions.
Target genes and regions involved in gene expression regulation and signaling pathways. These panels can help identify biomarkers associated with specific expression pathways and guide the development of targeted therapies. Explore our RNA Cancer Panel which targets over 1300 genes for gene expression, variant, and fusion detection.
Features of Our custom Cancer NGS Panel
The panel is an NGS assay designed to detect all types of variants in over 400 genes associated with somatic cell cancers.
Our in-house targeted enrichment platform allows us to customize Panel products in different packages for different genes and enrichment needs, such as core genes, 50 genes to 400 genes.
Stringent quality control throughout the pipeline workflow ensures accurate and reproducible sequencing.
Cost and effort savings by targeting selected genes with high sensitivity and specificity.
Detects all mutation types in a single assay, including SNV, insertional deletions, large insertional deletions, CNV, rearrangements, MSI, and TMB.
Sequencing Platforms: All types of sequencing devices, Illumina, MGI, PacBio, and Oxford Nanopore.
Bioinformatics results for large deletion analysis are available through a powerful bioinformatics system.
The panel's high performance ensures reliable and consistent sequencing results for customers, even when using DNA from low-quality clinical samples or FFPE.
Custom NGS Panel Contents
CDCAP Panel Contents
Options
Library Preparation Kit
- Sonicator-based standard kit
- Fragmentase-based standard kit
- Enzymatic Preparation kit (Fragmentation to ER /A-tailing in a single reaction)
Hybridization Kit
- Standard hybridization kit
- Enhanced hybridization kit
Sample Pooling Options
- Standard
- Multiplex
Double-Stranded cDNA Synthesis Kit
Clean Beads
CD Clean-up Beads
Polymerase Amplification Kit
CD Bioinformatics Service
Compatible Platforms
Illumina, MGI, PacBio, Nanopore
CDAMP Panel Contents
Options
Targeted Library Kit
-Targeted Library kit
- Molecular Barcodes Targeted Library kit
Primer Pools Options
- Standard Primers
- Enhanced Primers
Clean Beads
CD Clean-up Beads
CD Bioinformatics Service
Compatible Platforms
Illumina, MGI
How Does Our Custom NGS Panel Service Work?
1. Initial Consultation
Understand your research goals, sample types, and the specific genetic variants or genes you wish to target.
2. Panel Design
Create your NGS panel and optimize the design using our extensive library of genetic content and our expertise.
3. Validation
Conduct rigorous validation tests to meet the highest standards of accuracy and reproducibility.
4. Production & Delivery
Manufacture and ship the custom panel along with comprehensive documentation and support materials.
Our cancer NGS panel is offered in different configurations, including the Core, 50, 100, and 400 versions, to meet different requirements and research needs, which is designed to detect variants in all types of cancers, including breast, ovarian, prostate, colorectal and other types of cancer. Customers can choose the target genes that suit your purpose from the gene list.
Specimen requirements of our custom cancer screen panel
Specimen: FFPE, frozen tissue, cfDNA, RNA
Volume: 3ug DNA.
Collection: Paraffin block preferred; percentage of tumor in specimen should be >30%.
Container: Lavender-top (EDTA) tube or yellow-top (ACD) tube.
Our Gene NGS Panel Workflow
CD Genomics provides accurate and cost-effective panel sequencing and bioinformatics analysis of various somatic cancer-associated genes. Our dedicated team of experts performs quality management, following every procedure to ensure confident and unbiased results.
our Custom NGS Panel Service, you can obtain a highly customized and optimized NGS panel that precisely matches your research requirements. We look forward to working with you on your innovative discoveries, so please do not hesitate to contact us.
Reference
Pinsky PF. (2015) Principles of Cancer Screening. Surg Clin North Am. 95(5):953-66.
* For research purposes only, not intended for clinical diagnosis, treatment, or individual health assessments.
Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries.
