Homologous Recombination Repair (HRR) Reference Products

Current Status of HRR Research

Homologous Recombination Repair HRR Reference Products

DNA damage can occur during normal cellular processes or when exposed to external environments. there are several types of DNA damage, including single strand breaks (SSB), double strand breaks (DSB), base damage and cross-linking of DNA strands. DNA damage can lead to mutations, chromosomal aberrations and even cell death, and is a hallmark of various diseases. Therefore, cells have evolved multiple DNA repair mechanisms to counteract DNA damage and maintain genomic integrity. One of these mechanisms is homologous recombination repair (HRR), a complex DNA repair mechanism that corrects DSBs in DNA. Defects in the HRR pathway are associated with a variety of human diseases, including cancer and genetic disorders such as Fanconi anemia.

CD Genomics offers reliable HRR reference products to help you analyze mutations in genes involved in the HRR pathway in cancer.

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Homologous Recombination Repair (HRR) Reference Products Details

Our HRR reference products contain a variety of mutations associated with the HRR pathway, such as:

Gene

BRCA1	BRCA2	ATM	ATR	BLM	BRIP1
CDK12	CHEK1	CHEK2	FANCA	FANCC	FANCD2
FANCE	FANCF	FANCI	FANCL	FANCM	NBN
PALB2	RAD50	RAD51	RAD51B	RAD51D	RAD54L
RPA1	-	-	-	-	-

Our technical team can customize gDNA, ctDNA, and FFPE for the above mutations, which are widely used for the registration of HRR test kits and daily quality control of HRR tests.

Origin

Our HRR reference products are derived from cell lines close to clinical samples.

Product Highlights

Cover most genes of HRR pathway.
Customizable for Pathogenic, likely Pathogenic, VUS, likely benign, benign mutation loci.
Can mix specific mutation sites.
Customizable mutation frequency range of 0%-100%.
ddPCR can be customized for validation.
Consistent and reliable quality.

Applications

Can be used as reference for HRR assay kits.
Can be used as a negative/positive reference within HRR assay kits.
Used for parallel comparison of HRR test kits.
As a daily quality control for HRR assay.
As inter-room quality assessment of HRR assay.

* For Research Use Only. Not for use in diagnostic procedures.

Explore Our Homologous Recombination Repair (HRR) Reference Products:

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Cat. No.	Product Name	Brief Description	Inquiry	Basket
HRRR001	CD HRR Reference	CD HRR Reference contains mutations related to the HRR pathway and can be customized in the form of gDNA, ctDNA or FFPE, which are ideal reference products for HRR test kit registration and daily quality control of HRR tests.