Drug Safety for Adult

Description

Personalized medicine is particularly important for disease treatment whereby many clinically used drugs exhibit a large interindividual pharmacokinetic and pharmacodynamic variability. This variability can lead to therapeutic failure or severe toxicity. Understanding of how genetic variations influence drug disposition and action could help in disease therapy based on individual’s genetic makeup. Pharmacogenomics is the study of how variations in the human genome affect the response to medications.

CD Genomics provides a predesigned panel, which covers 159 pharmacogenomics related genes for adults. Utilizing amplicon sequencing technology by illumina system can provide more efficient and accurate targeting for the 159 genes and mutations. This panel can help to guide for selecting appropriate drugs and dosage for individual patients, for achieving personalized medication. If necessary, you can choose genes that fit your requirements.

Diseases associated with the 159 genes, including psychiatry, neurology, rheumatology, immunology, cardiovascular, oncology, pain, infection, respiratory, gastroenterology, endocrinology, urology, hematology, obstetrics and gynecology, dentistry, ophthalmology.

Gene List of Drug Safety for Adult Panel

ABCB1 ABCC4 ABCCB ABCG2 ACE ADCY9 ADD1 ADIPOQ ADORA2A ADRA2A
ADRB1 ADRB2 AGT AGTR1 ALDH2 ANKKI APOA5 APOE ATIC BCHE
C11orf65 C8orf34 CALU CBR3 CCHCR1 CDA CDK4 CEP72 CES1 CETP
CFTR CHIA CHRNA3 CHRNB2 CNR1 COL22A1 COMT COQ2 CREB1 CRHR1
CRHR2 CYP1A2 CYP1B1 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP3A4 CYP3A5
CYP4F2 DBH DPP6 DPYD DRD1 DRD2 DRD3 DYNC2H1 EGF EGFR

(check the Drug Safety for Adult Panel Gene List for more genes)

Highlights of Drug Safety for Adult Panel Sequencing Service

  • Target-enrichment sequencing by Illumina provides ultra-deep sequencing to target specific genomic regions with lower costs.
  • High coverage uniformity ensures the sequencing data more efficiency.
  • SNVs, indels can be detected.
  • Strict quality control throughout the pipeline workflow to ensure the accuracy and repeatability of the sequencing.
  • Fast turnaround time.

Applications of Drug Safety for Adult Panel Sequencing

  • Precise medication guidelines
  • Pharmacogenomics

Service Specifications

Service Specifications

Sample Requirements

  • Sample types for genome DNA from buccal swabs, blood.
  • Recommended amount: 2μg
  • Minimum amount: 1μg
  • Collection: DNA samples are stored in TE buffer or equivalent. Buccal swabs are collected by routine buccal swab collection.
Service Specifications

Sequencing

  • Illumina PE150
  • Enrichment Method: Amplicon sequencing
  • More than 80% of bases with a ≥ Q30 quality score
  • Recommended sequencing depth: ≥ 500x
Service Specifications

Bioinformatics Analysis

We provide customized bioinformatics analysis including:

  • Read alignment
  • Variant calling/Annotation

Gene Panel Workflow

CD Genomics provides the accurate and cost-effective pharmacogenomics sequencing and bioinformatics analysis. Our professional expert team executes quality management, following every procedure to ensure confident and unbiased results. The general workflow for pharmacogenomics sequencing is outlined below.

Gene Panel Workflow

For more information about the pharmacogenomics testing or need other amplification requirements, please contact us.

References:

  1. Jing L, et al. Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy. Pharmacogenomics and Personalized Medicine, 2011. 4, 11-33.
  2. Sarah R, et al. Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management. Pharmacogenomics and Personalized Medicine, 2010. 3, 129-143.
* For Research Use Only. Not for use in diagnostic procedures.

Online Inquiry
  • Please input "genomics" as verification code.

  • 45-1 Ramsey Road, Shirley, NY 11967, USA
  • 1-631-275-3058 (USA)
           44-208-144-6005 (Europe)
  • 1-631-614-7828
  • info@cd-genomics.com
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