Genomic deoxyribonucleic acid (gDNA) is the complete genetic material or DNA present in the nucleus of an organism's cells. gDNA is organized as chromosomal DNA and, unlike extrachromosomal DNA such as plasmids, contains all the genes and regulatory sequences that determine the characteristics of an individual. gDNA is important in the study of genetics and molecular biology because it contains the complete genetic information of an organism. Cancer is a complex disease caused by the accumulation of genetic mutations in cellular DNA, leading to uncontrolled growth and development of tumors. The study of gDNA can help identify these mutations and understand how they contribute to the development and progression of cancer. In addition, gDNA analysis can provide information about the overall genetic profile of cancer. In conclusion, gDNA analysis plays a crucial role in tumor research and treatment in oncology.
CD Genomics offers a wide range of oncology gDNA quality control products to assist you in gDNA analysis for oncology research and therapy.
Our accurate and stable tumor gDNA quality control products can mimic tissue-extracted gDNA samples to help you identify specific mutations in cancer cells that may contribute to disease progression and develop targeted therapies to target these mutations, resulting in more effective treatments with fewer side effects.
Our tumor gDNA quality controls are derived from cell lines with complete traceability documentation. Our laboratory's stable and reliable production system will ensure the monoclonal and passaged culture of cells and the stable production of gDNA quality controls with homogeneous genetic backgrounds that mimic clinical samples.
The production process is specified as follows:
(1) Cell lines with well-defined mutation loci are obtained by gene editing or cell screening.
(2) Mixing gDNA with defined mutation sites and mutation frequencies through a specific production process.
(3) Obtain gDNA controls with multiple mutation sites and frequencies.
(4) Validation by ddPCR to ensure that each batch of gDNA controls produced has a precise and stable mutation frequency.
Our tumor gDNA quality control products contain a variety of mutation types, such as SNV, insertion/deletion, copy number variation/amplification, gene fusion, etc.
Our tumor gDNA quality control products contain several popular cancer-related gene mutation loci, such as EGFR, KRAS, ALK, BRAF and other genes.
These panel standards can be used to monitor the quality assessment of NGS or dPCR based tumor testing workflows. The multi-locus quality control products reduce the need for multiple standards to be used in the quality control process and therefore simplify the workflow for customers in the quality control process.
Explore Our Oncology gDNA Quality Control Products:
| Cat. No. | Product Name | Brief Description | Inquiry | Basket |
|---|---|---|---|---|
| OGQC001 | CD Pan-Tumor gDNA Standards | CD Pan-Tumor gDNA Standards covering 450 COSMIC mutation loci can be used to monitor quality assessment of NGS or dPCR based tumor detection workflows. | ||
| OGQC002 | CD Tumor SNV 5% gDNA Standard II | CD Tumor SNV 5% gDNA Standard II is widely used in NGS. | ||
| OGQC003 | CD Tumor Structural Variation 5% gDNA Standard | CD Tumor Structural Variation 5% gDNA Standard is widely used in NGS. | ||
| OGQC004 | CD Tumor SNV Wild Type gDNA Standard | CD Tumor SNV Wild Type gDNA Standard is widely used in NGS. | ||
| OGQC005 | CD 5% BRAF V600E gDNA Standard | CD 5% BRAF V600E gDNA Standard is suitable for the verification of accuracy, reproducibility, stability and detection limits of the whole process of qPCR and Sanger sequencing. | ||
| OGQC006 | CD 5% EGFR L858R gDNA Standard | CD 5% EGFR L858R gDNA Standard is suitable for the validation of accuracy, reproducibility, stability, and detection limits for the whole process of qPCR and Sanger sequencing. | ||
| OGQC007 | CD 5% EGFR V769-D770insASV gDNA Standard | CD 5% EGFR V769-D770insASV gDNA Standard is suitable for the validation of accuracy, reproducibility, stability, and detection limits for the whole process of qPCR and Sanger sequencing. | ||
| OGQC008 | CD 5% KRAS G13D gDNA Standard | CD 5% KRAS G13D gDNA Standard is suitable for the validation of accuracy, reproducibility, stability, and detection limits for the whole process of qPCR and Sanger sequencing. | ||
| OGQC009 | CD 5% KRAS G12D gDNA Standard | CD 5% KRAS G12D gDNA Standard is suitable for the validation of accuracy, reproducibility, stability, and detection limits for the whole process of qPCR and Sanger sequencing. | ||
| OGQC010 | CD 5% PIK3CA H1047R gDNA Standard | CD 5% PIK3CA H1047R gDNA Standard is suitable for the validation of accuracy, reproducibility, stability, and detection limits for the whole process of qPCR and Sanger sequencing. |
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