Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system caused by a combination of genetic and environmental factors. MS is the second leading cause of neurological disability in young adults in some western countries. According to the 2013 statistics, about 2.3 million people worldwide suffer from multiple sclerosis, and the data may be underestimated due to the relative lack of data for large populations such as India and China. The early features of multiple sclerosis are usually acute neurological deficits, which depend on the area of the central nervous system with acute inflammatory demyelinating lesions and the extent of inflammatory response. However, the mechanism of the formation of myelin regeneration is not fully understood.
Genes involved in the development of MS mainly include myelination regulators, T cell activation and signaling regulators, and adaptive immune regulators. The human leukocyte antigen (HLA) complex is the first identified locus associated with multiple sclerosis. But so far, no research scholars have fully explained how it participates in the occurrence of MS. The hydroxylase encoded by the CYP27B1 gene hydroxylates the inactive form of vitamin D3 to its biologically active form, 1,25-dihydroxyvitamin D3. This may increase the antigen-specific response associated with T cells and trigger inflammation. In addition, studies have shown that low level of vitamin D in serum is associated with the occurrence of MS. Interleukin-8 (IL-8) is expressed in a variety of inflammatory and autoimmune diseases. It is suggested that IL-8 can induce leukocytes to transfer to the central nervous system and induce phagocytosis at the site of infection, which is related to the damage of the blood-brain barrier. Modern genetic methods (genome-wide association studies) have revealed at least twelve other genes outside the IL-8 locus that modestly increase the probability of MS such as COL11A2, DPH5, EXTL2, ALAS2, CA1, SNCA, etc.
In order to provide better services for clinical research of IL-8 and other associated genes, our custom multiple sclerosis panel platform provides a comprehensive library of multiple sclerosis panels from which you can select the genes involved for testing. We provide professional targeted sequencing technology to effectively detect, validate and screen key genes affecting the development of multiple sclerosis. Thus, it can provide a new way to find the pathogenesis of MS, which is helpful for the research of new treatment strategies.
For more information about the Custom Multiple Sclerosis Panel or need other amplification requirements, please contact us.