Arrhythmia is a relatively common disease of the cardiovascular system in the clinic. There are many factors that can cause arrhythmia in patients. Arrhythmia can cause organic diseases, such as coronary heart disease. The main treatment for clinical arrhythmias at this stage is still medication. One of the important factors in the occurrence of arrhythmia is the late sodium current. The late sodium current is a small continuous inward current that develops during the plateau phase after cardiomyocyte depolarization, caused by sodium ions entering the cardiomyocytes through the incompletely closed sodium channel. The late sodium current can affect the action potential duration and cause complex abnormalities, resulting in arrhythmia. Typical symptoms of arrhythmias include, but are not limited to palpitations, dizziness, syncope, shortness of breath, seizures, cardiac arrest and sudden cardiac death.
Arrhythmia is a cardiovascular disease caused by genetic factors. A variety of genes associated with arrhythmia syndrome have been reported. ABCC9 is one of the reported genes encoding a potassium channel protein subunit SUR2 protein that regulates the extent of vasoconstriction and membrane potential. There is sufficient evidence that the genetic variations of ABCC9 in humans are closely related to dilated cardiomyopathy, myocardial infarction and familial atrial fibrillation. In addition, the G protein beta subunit 5 involved in inhibitory G protein signaling is encoded by the GNB5 gene. And sufficient experiments have shown that gnb5 knockout model animals have abnormal symptoms in heart, nerve and ophthalmology, supporting the direct effect of GNB5 in controlling heart rate and hypotonia. The SCN5A gene is involved in many arrhythmias and cardiomyopathy processes, including sinus node and atrioventricular sarcoidosis, atrial arrhythmia, dilated cardiomyopathy, and early cardiac arrest. Except for ABCC9, GNB5 and SCN5A, there are other highly relevant genes such as ANK2, CDKN1A, SCN10A, NFIA, CEP85L and RYR2.
Based on the latest research report, we have selected a variety of representative genes that are highly correlated with arrhythmia. You can select the genes you want in the panel library or customize your exclusive panel. We offer specialized targeted sequencing technologies to detect low-frequency genetic variants.
For more information about the Custom Arrhythmia Panel or need other amplification requirements, please contact us.