CDAmp™ Myeloid Neoplasms Panel Kit

CAT	Size	Inquiry	Basket
PNO012-1	24rxn
PNO012-2	96rxn

Overview

Product Description

CDAmp™ Myeloid Neoplasms Panel for comprehensive mutation profiling of myeloid malignancies via multiplex PCR-based targeted resequencing utilizing proprietary CDAmp technology. It includes the coding sequence (CDS) regions of 18 genes and hotspot mutation regions of 40 genes. It is designed for disease investigation and classification, molecular feature correlation analysis, therapeutic guidance research, and genetic screening of myeloid neoplasms such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and MDS/MPN overlap syndromes.

Features

Key Features & Advantages

Comprehensive Mutation Profiling
· Detects somatic mutations in 18 genes with full CDS coverage and 40 genes with targeted hotspot regions, including SNVs, indels, and internal tandem duplications (e.g., FLT3).
Fast, Simplified Workflow
· Prepare sequencing-ready libraries in a single tube within 5 hours, with less than 2 hours of hands-on time.
Superb Coverage Uniformity
· Ensures high uniformity of coverage even in high-GC regions for reliable variant calling.

Specifications

Product Specifications

Enrichment Method:	Multiplex PCR Amplification
Species:	Human
Variant Types:	SNV、Indel、ITD
Target Size:	6.5 Kb
Primer Count:	766
Amplicon Length:	215bp(169-260bp)
Cancer Type:	AML、MDS、MPN、MDS/MPN
Number of Genes:	58
Sample Type:	blood,Bone Marrow etc.
Input DNA/RNA:	10-80ng
Method:	NGS
Sequencing Platform:	Illumina; Ion Torrent
Storage:	Store at -20 °C.

Gene List

ABL1	ANKRD26	ASXL1	ATRX	BCOR	BCORL1	BRAF
CALR	CBL	CBLB	CBLC	CDKN2A	CEBPA	CSF3R
CUX1	DDX41	DNMT3A	ETNK1	ETV6	EZH2	FLT3
GATA1	GATA2	GNAS	HRAS	IDH1	IDH2	IKZF1
JAK2	JAK3	KDM6A	KIT	KMT2A	KRAS	MPL
NF1	NPM1	NRAS	PDGFRA	PHF6	PIGA	PPM1D
PTEN	PTPN11	RAD21	RUNX1	SETBP1	SF3B1	SMC1A
SMC3	SRSF2	STAG1	STAG2	TET2	TP53	U2AF1
WT1	ZRSR2