Details
| Product Infomation | |
|---|---|
| Product Description: | The CD Lung Cancer RNA Panel (ALK, RET, ROS1, MET) combined reverse transcription, subsequent mutant, and reference gene amplification, and detected a total of 47 mutation sites in 8 reactions. And the kit minimizes hands-on time and reduces the risk of contamination. Non-small cell lung cancer (NSCLC) is often found to be associated with abnormal tyrosine kinase activity, which is associated with chromosomal translocations of ALK, ROS1, and RET. To predict response to tyrosine kinase inhibitors (TKIs) (crizotinib, ceritinib, and alectinib) in NSCLC by detecting mutations in ALK and ROS1. Lung cancer patients with RET fusion genes may be candidates for RET inhibitors (vandetanib and cabozantinib) already approved for thyroid cancer treatment. |
| Features: | Works with FFPE and fresh frozen samples. One step RT-qPCR. Simple setup and interpretation. Includes internal control. ALK Fusion Gene Variant Chromosomal Translocation EML4-ALK E13; A20 E20; A20 E20; ins18A20 E6; A20 E6ins33; A20 E6; ins18A20 E14ins11; del49A20 E2; A20 E2; ins117A20 E13; ins69A20 E14; del14A20 E14; del36A20 E17; ins30A20 E17ins61; ins34A20 E17del58ins39; A20 E17ins65; A20 E17; ins68A20 E15del60; del71A20 E18; A20 E3; ins53A20 E6; A19 |
| Sequencing Platform: | Real-time PCR |
| Storage: | Store in < -20℃ freezer. Repeated thawing and freezing should be avoided. |
| Method: | Real-time qualitative PCR |
| Equipment Required: | Real-time PCR instrument (VIC, FAM and CY5) |
| Required Reagents: | RNA extraction kit, pipettors and filter tips |
| ShippingCondition: | Dry ice |
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