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info@cd-genomics.com
info@cd-genomics.com
The CD c-KIT and PDGFRA RT-PCR Kit is a polymerase chain reaction (PCR)-based assay that uses allele-specific primers to identify mutations present in the c-KIT and PDGFRA genes. More than 80% of gastrointestinal stromal tumors (GISTs) harbor activating mutations in c-KIT, and 5-7% of GISTs harbor PDGFRA mutations. Mutations in c-KIT and PDGFRA are both cancer biomarkers, predict response to targeted therapy, and provide prognostic information.
Gene Mutation COSMIC ID
PDGFRA EX18_p.D842V COSM736
c-Kit EX11_ p.V559D COSM1252
EX11_p.V559G COSM1253
EX11_p.V560D COSM1257
EX11_W557R COSM1216
EX17_p.D816H COSM1311
EX17_p.D816V COSM1314
EX11_p.L576P COSM1290
EX13_p.K642E COSM1304
EX9_p.Y503_F504insAY COSM1326
EX11_p.W557_E561del COSM1332
EX11_p.W557_K558del COSM1217
EX11_p.W557_V559>C COSM1233
EX11_p.W557_V559>F COSM1226
EX17_p.K818R COSM1315
EX17_p.N822H COSM1318
EX17_p.N822Y COSM19109
EX11_p.V559A COSM1255
EX11_p.W557G COSM1221
EX17_p.D820Y COSM12710
EX17_p.N822K COSM1322
EX17_p.D820G COSM1316
| Sequencing Platform: | Real-time PCR |
| Storage: | Store in < -20℃ freezer. Repeated thawing and freezing should be avoided. |
| Method: | Real-time qualitative PCR |
| Equipment Required: | Real-time PCR instrument (FAM, ROX, CY5 and VIC) |
| Required Reagents: | DNA extraction kit, pipettors and filter tips |
| ShippingCondition: | Dry ice |
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