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CD Ras RT-PCR Panel

CAT	Size	Inquiry	Basket
PN208	50 reactions

OverviewFeaturesSpecifications

Overview

Product Description

The CD Ras RT-PCR Panel can be used to screen for mutations found in exons 2, 3, and 4 of the KRAS and NRAS genes. KRAS and NRAS belong to the GTPases of the RAS family and play an important role in the MAPK signaling pathway. Exon 2 (codons 12/13), exon 3 (codons 59/61), and exon 4 (codons 117/146) are found in various cancers including metastatic colorectal cancer activating mutations. It was recently found that colorectal cancer patients with KRAS and NRAS mutations respond less to anti-EGFR-targeted therapy than patients without mutations.

Features

Key Features & Advantages

Gene Mutation Group
KRAS G12A, G12D, G12R, G12V, G13D 1
G12C, G12S 2
Q61H, Q61L, Q61R, A59E, A59G, A59T 3
K117N, K117R, K117E 4
A146T, A146P, A146V 5
NRAS G12D, G12C, G12S, G13R, G13V, K117R 6
Q61H, Q61L, Q61K, Q61R 7
A59D, A59T, A146T 8

Specifications

Product Specifications

Sequencing Platform:	Real-time PCR
Storage:	Store in < -20℃ freezer. Repeated thawing and freezing should be avoided.
Method:	Real-time qualitative PCR
Equipment Required:	Real-time PCR instrument (FAM and VIC)
Required Reagents:	DNA extraction kit, pipettors and filter tips
ShippingCondition:	Dry ice

* For research purposes only, not intended for clinical diagnosis, treatment, or individual health assessments.

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