Leveraging innovative probe design, our hybrid capture-based pathogen panel enables ultra-broad screening of bacteria, viruses, fungi, parasites, and other pathogens in research specimens.
Key Features:
Next-generation sequencing (NGS) delivers superior sensitivity compared to traditional methods. This enables simultaneous detection of low-frequency mutations across thousands of targets. Unlike conventional Sanger sequencing, which frequently misses such variants, NGS achieves significantly greater sequencing depth – dramatically lowering detection thresholds. Three Primary NGS Approaches for Pathogen Detection:
Hybrid Capture NGS
This technique enriches target sequences using pre-designed probes that hybridize to specific pathogen DNA/RNA. Probes precisely cover critical pathogen regions, including virulence factors and antimicrobial resistance markers, ensuring high sensitivity. Hybrid capture optimally balances robust host background suppression with cost efficiency, making it ideal for comprehensive detection panels and detailed resistance/virulence profiling.
PCR Amplicon NGS
Leveraging multiplex PCR, this method amplifies predefined target regions prior to library construction and sequencing. It provides exceptional speed and sensitivity for known targets at lower costs. PCR amplicon NGS excels in rapid confirmation of common pathogens, routine surveillance programs, and high-throughput screening applications.
Metagenomic NGS (mNGS)
mNGS performs untargeted sequencing of all nucleic acids in a sample through unbiased fragmentation and library preparation. As a hypothesis-free discovery tool, it provides comprehensive pathogen agnostic coverage. This approach is typically reserved for complex cases: investigating challenging infections when standard tests fail, identifying emerging pathogens, and supporting research investigations.
Explore Our Comprehensive Pathogen Panel:
| Cat. No. | Product Name | Brief Description | Inquiry | Basket |
|---|---|---|---|---|
| PNP001 | CDCap™ Ultra-Comprehensive Pathogen Kit | CDCap™ Ultra-Comprehensive Pathogen Kit employs probe hybridization capture to detect 7,000+ pathogens and >1,000 AMR/virulence genetic markers. Its ~8,000 probes minimize host background while ensuring broad, specific enrichment for preclinical research and epidemiology. | ||
| PNP002 | CDCap™ Comprehensive Pathogen Kit | CDCap™ Comprehensive Pathogen Panel: Hybridization capture-based NGS kit detecting 435 pathogens, including resistance/virulence markers for preclinical research. |
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