CDCap™ Solid Tumor Mid Panel Kit

CAT	Size	Inquiry	Basket
PNO002-1	24rxn
PNO002-2	96rxn

Overview

Product Description

CD Genomics designed this panel to detect coding regions of 122 tumor-associated genes, intronic regions of 10 hotspot fusion genes, 19 classic microsatellite loci, and 219 chemotherapy-related loci using hybrid capture technology. Aligned with the latest FDA-approved NGS in vitro diagnostic standards and informed by panel frameworks from leading cancer centers(eg.MSKCC\MD Anderson). The panel combines focused genomic coverage with comprehensive mutation profiling to address diverse detection needs across multiple cancer types. It provides complete coverage of loci related to targeted targeted therapeutic mechanisms, chemotherapeutic agent toxicity/sensitivity, and immune pathway-associated genes.

Features

Key Features & Advantages

Comprehensive Mutation Profiling
· Detects diverse variant types, including SNVs, indels, fusions, microsatellite instability (MSI), and chemotherapy-related markers.
Optimized for Liquid Biopsy
· Streamlined panel design with UMI tagging enhances sensitivity and accuracy for low-input cfDNA detection.
Superior Hybrid Capture Performance
· Leverages the CD genomic hybridization capture system for uniform, high-efficiency target enrichment.
Customizable Research Solutions
· Flexible panel configurations allow researchers to add or remove regions to meet specific study goals.

Specifications

Product Specifications

Enrichment Method:	Probe Hybridization Capture
Species:	Human
Variant Types:	SNV、Indel、Fusion、CNV、MSI
Target Size:	438.3Kb
Cancer Type:	Pan-Cancer
Number of Genes:	122
Sample Type:	Tissue、FFPE、blood
Input DNA/RNA:	cfDNA ≥20ng, gDNA ≥30ng
Method:	NGS
Sequencing Platform:	Illumina
Storage:	Store at -20 °C.

Data

1、Excellent Dual-Platform Performance：Highly Efficient Capture and Uniform Coverage

Gene List

Table1:Gene List

AKT1	ABL1	ABL2	AKT3	ALK	APC	AR	ARAF	ARID1A	ATM	ATR	BAP1
BARD1	BRAF	BRCA1	BRCA2	BRIP1	CCND1	CDH1	CDK12	CDK4	CDK6	CDKN2A	CDX2
CHEK2	CTNNB1	DDR2	DICER1	EGFR	EPCAM	ERBB2	ERBB3	ERBB4	ERCC2	ESR1	EZH2
FBXW7	FGFR1	FGFR2	FGFR3	FGFR4	FH	FLCN	FLT3	FOXA1	FOXL2	GATA3	GNA11

Table2:Fusion Gene List

ALK

CD74

ETV6

FGFR1

FGFR2

FGFR3

NTRK1

NTRK2

RET

ROS1

FAQs

What is the recommended sequencing depth for the pan-cancer detection kit?

The recommended sequencing depth for pan-cancer detection kits depends on the required limit of detection (LOD) for variants specified by the client. For example, to detect variants at a frequency of 1%, a sequencing depth of approximately 500X is required. The pan-cancer detection kit can achieve 500X coverage with 1 Gb of raw data. Additionally, by incorporating UMI adapters, the kit can analyze cell-free DNA (cfDNA) in plasma samples, enabling a detection limit as low as 0.01%.

* For research purposes only, not intended for clinical diagnosis, treatment, or individual health assessments.