Details
| Product Infomation | |
|---|---|
| Product Description: | The CD Ras RT-PCR Panel can be used to screen for mutations found in exons 2, 3, and 4 of the KRAS and NRAS genes. KRAS and NRAS belong to the GTPases of the RAS family and play an important role in the MAPK signaling pathway. Exon 2 (codons 12/13), exon 3 (codons 59/61), and exon 4 (codons 117/146) are found in various cancers including metastatic colorectal cancer activating mutations. It was recently found that colorectal cancer patients with KRAS and NRAS mutations respond less to anti-EGFR-targeted therapy than patients without mutations. |
| Features: | Gene Mutation Group KRAS G12A, G12D, G12R, G12V, G13D 1 G12C, G12S 2 Q61H, Q61L, Q61R, A59E, A59G, A59T 3 K117N, K117R, K117E 4 A146T, A146P, A146V 5 NRAS G12D, G12C, G12S, G13R, G13V, K117R 6 Q61H, Q61L, Q61K, Q61R 7 A59D, A59T, A146T 8 |
| Sequencing Platform: | Real-time PCR |
| Storage: | Store in < -20℃ freezer. Repeated thawing and freezing should be avoided. |
| Method: | Real-time qualitative PCR |
| Equipment Required: | Real-time PCR instrument (FAM and VIC) |
| Required Reagents: | DNA extraction kit, pipettors and filter tips |
| ShippingCondition: | Dry ice |
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