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info@cd-genomics.com
info@cd-genomics.com
The CD NRAS RT-PCR Kit is used to detect the mutation of NRAS to judge cancer. NRAS belongs to the GTPase of the RAS family and plays a major role in the MAPK signaling pathway. Activating mutations in exon 2 (codon 12/13), exon 3 (codon 61), and exon 4 (codon 146) occur in cancers including melanoma, colorectal cancer, lung cancer, hepatocellular carcinoma, in various cancers, including myelogenous leukemia and thyroid cancer.
Exon Mutation Name Nucleotide Change Amino Acid Change
2 G12C c.34G>T Glycine (G) to Cystein (C)
G12D c.35G>A Glycine (G) to Aspartic acid (D)
G12S c.34G>A Glycine (G) to Serine (S)
G13V c.38G>T Glycine (G) to Valine (V)
G13R c.37G>C Glycine (G) to Arginine (R)
3 Q61K c.181C>A Glutamine (Q) to Lysine (K)
Q61R c.182A>G Glutamine (Q) to Arginine (R)
Q61L c.182A>T Glutamine (Q) to Leucine (L)
Q61H c.183A>C & c.183A>T Glutamine (Q) to Histidine (H)
4 A146T c.436G>A Alanine (A) to Threonine (T)
| Sequencing Platform: | Real-time PCR |
| Storage: | Store in < -20℃ freezer. Repeated thawing and freezing should be avoided. |
| Method: | Real-time qualitative PCR |
| Equipment Required: | Real-time PCR instrument (FAM and VIC) |
| Required Reagents: | DNA extraction kit, pipettors and filter tips |
| ShippingCondition: | Dry ice |
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