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Unlock genome-wide insights into DNA methylation with our advanced microarray-based service. CD Genomics offers an end-to-end solution—covering everything from sample preparation to bioinformatics analysis—leveraging Illumina Infinium 935K, and 270K array platforms.
Whether you're exploring disease pathways, conducting an epigenome-wide association study (EWAS), or investigating gene regulation, our platform empowers you to analyze methylation at key CpG sites with high accuracy and cost-efficiency.
The Human DNA Methylation Microarray is a high-throughput epigenetic profiling technology that allows researchers to assess the methylation status of hundreds of thousands of CpG sites across the human genome—all in a single experiment. Powered by Illumina’s Infinium platform, this method uses sequence-specific probes that bind to bisulfite-converted DNA, producing quantitative methylation data based on fluorescent signal intensity.
Compared to traditional methylation methods like MSP, MeDIP, or whole-genome bisulfite sequencing (WGBS), microarrays offer a superior balance of cost, scalability, and reproducibility. This makes them especially well-suited for large cohort studies, epigenome-wide association studies (EWAS), and integrative multi-omics research.
CD Genomics currently provide the Infinium Human Methylation 935K and 270K arrays, offering broader genomic coverage and updated probe design compared to previous versions such as the 850K array. The 935K array includes enhanced content in regulatory regions and non-CpG methylation sites, making it more suitable for current epigenomic studies.
Schematic of the procedures for genome-wide DNA methylation analysis. (Lee, Ja-Rang, et al., BMC genomics, 2018)
When it comes to studying epigenetic changes, each technology offers unique benefits. At CD Genomics, our DNA methylation microarray platform is designed for cost-effective, genome-wide coverage of key CpG sites—making it the ideal tool for high-throughput research and large population studies.
Unlike sequencing-based approaches, methylation arrays strike the perfect balance between efficiency, affordability, and reliability, especially for exploratory studies or large cohort designs.
| Technology | Coverage | DNA Input | Cost-Effectiveness | Workflow Efficiency | Ideal For |
|---|---|---|---|---|---|
| Methylation Microarrays (270K / 935K) | Genome-wide CpG hotspots & regulatory elements | 50–1,000 ng | ★★★★☆ (High throughput) | ★★★★★ (Rapid batch processing) | Population studies, EWAS, exploratory research |
| WGBS | Entire genome (high sequencing depth required) | ≥1,000 ng | ★★☆☆☆ (High cost) | ★★☆☆☆ (Complex, time-intensive) | Fine-scale epigenetic mapping, in-depth discovery research |
| RRBS | CpG-rich regions | ≥500 ng | ★★★☆☆ (Moderate) | ★★☆☆☆ (Sample/data-intensive) | Targeted methylation studies, mid-scale projects |
At CD Genomics, we offer three high-performance DNA methylation microarray platforms based on Illumina's Infinium technology. Each service is optimized for a different research focus—from comprehensive genome-wide methylation analysis to cost-effective screening of phenotype-linked CpG sites. Whether you're investigating cancer epigenetics or conducting large-scale population studies, our flexible options ensure you get the best-fit solution.
Service Comparison: CD Genomics Methylation Array Platforms
| Platform | Coverage | DNA Input | Throughput | Best Suited For |
|---|---|---|---|---|
| Infinium Human Methylation 935K | 935,000+ CpG sites, updated to the latest genome build; includes CNV detection capability | 250 ng | 8 samples per chip | Complex disease epigenetics, rare disease studies, tumour biomarker discovery |
| Infinium Methylation Screening Array 270K | 270,000 CpG sites focused on phenotype-related loci | 50 ng | 48 samples per chip | EWAS, environmental exposure research, population-scale methylation profiling |
All platforms utilize Illumina's gold-standard Type I + Type II probe chemistry, ensuring high sensitivity, consistent results, and full compatibility with FFPE samples.
At CD Genomics, we prioritize efficiency and reliability across every step of our DNA methylation microarray service. From project planning to data delivery, our streamlined workflow ensures high-quality results that help researchers move faster toward discovery.
Requirement Discussion
Experimental Plan Customization
Support for Multiple Human Sample Types
DNA Purity Assessment
Bisulfite Treatment
Illumina Infinium 935K/270K Arrays
8–48 Samples per Chip
Illumina iScan System
Single-Base Resolution Methylation Detection
Quality Control
Methylation Level Analysis
Differential Methylation Detection
Standardized Report Delivery
At CD Genomics, we go beyond raw data—our comprehensive bioinformatics reports are designed to support peer-reviewed publication and in-depth epigenetic discovery. From quality metrics to multi-dimensional visualization, you’ll have everything you need to interpret and present your methylation data confidently.
✅ Standard Deliverables
Our standard deliverables provide everything needed for basic methylation data interpretation and visualization:
🔍 Advanced Modules (Optional Add-ons)
Available as customizable bioinformatics services for deeper biological insights and publication-ready figures:
To ensure accurate, high-quality results from your DNA methylation microarray, please prepare samples according to the following standards:
| Sample Type | Key Requirements | Storage & Shipping | Recommended DNA Concentration | Notes |
|---|---|---|---|---|
| Cell Samples | ≥5×10⁶ cells | Flash-freeze in liquid nitrogen; store at −80°C; ship on dry ice | N/A | Fresh or cultured cells accepted |
| Tissue Samples | ≥100 mg tissue or slices | Flash-freeze in liquid nitrogen; store at −80°C; ship on dry ice | N/A | Avoid repeated freeze–thaw cycles |
| DNA Samples | High-purity genomic DNA | −20°C for short-term; −80°C for long-term; ship on ice packs | ≥50 ng/μL; ≥500 ng total | Must be free of RNA/protein; TE buffer or nuclease-free water |
✅ Label all samples clearly and seal packaging tightly to avoid degradation or contamination during transit.
📬 For unusual sample types or special conditions, feel free to consult our expert team.
At CD Genomics, we don't just deliver data—we deliver discovery.
with over a decade of microarray experience
from sample handling to final data
—rich visualisation and complex statistics included
—dedicated project manager + domain experts
to protect your IP and publication rights
CD Genomics' Human DNA Methylation Microarray service is purpose-built for high-throughput epigenetic studies. Whether you're mapping methylation across large cohorts or exploring disease mechanisms, our platform offers unmatched scale, accuracy, and flexibility.
Quickly generate high-resolution methylation profiles across hundreds of thousands of CpG sites to identify epigenetic patterns in tissues, conditions, or populations.
Combine DNA methylation data with transcriptome, miRNA, or proteome datasets to uncover regulatory networks and deepen insights into gene expression control.
Detect statistically significant methylation changes linked to disease states, environmental exposures, or clinical phenotypes using cohort-based or case-control designs.
Characterise tumour-specific methylation differences between normal and malignant tissues, across cancer subtypes, or at different disease stages to uncover regulatory drivers.
Track dynamic methylation changes across developmental stages or under environmental stimuli to understand how epigenetic mechanisms shape adaptation and growth.
Identify candidate epigenetic biomarkers for early-stage drug research or assess methylation-based indicators of drug response and treatment efficacy.
Selected publications from researchers utilizing CD Genomics' DNA methylation analysis services for advanced epigenetic research.
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