Gut Microbiota and Gastrointestinal Diseases
The gastrointestinal tract is host to an abundant and diverse population of microbes including bacteria, viruses, and microbial eukaryotes. The gut microbiota is a critical regulator of body homeostasis that impacts virtually all systems in the body. Within the wide spectrum of microbes, some are true commensals that have no noticeable effect on host physiology, some others are beneficial to human health by providing the host with nutrients or defenses against other pathogenic microbes, and of course, there are also other microbes that are harmful either by acting as acute pathogens with a range of virulence or by promoting chronic disease. It is anticipated that by studying microbiota and determining its changes during diseases, the research will offer insight into the pathogenesis of diseases as well as novel approaches to relieve human suffering.
The gut microbiome functions like an active metabolic organ contributing to nutrient digestion and absorption, immune function, and metabolic activity necessary for health. But when a disturbance occurs to microbiota composition, it could affect the host in many ways such as causing dysbiosis, arousing immunologic response, and influencing host metabolism, which almost impacts all systems in the body and has the most direct correspondence with the gastrointestinal tract and induces numerous gastrointestinal diseases that we provide research solutions for:
◆ Ulcerative colitis
◆ Clostridioides difficile Infection (CDI)
◆ Recurrent Clostridium Difficile Infection (RCDI)
◆ Crohn's disease
◆ Chronic constipation
◆ Inflammatory Bowel Disease (IBD)
◆ Irritable Bowel Syndrome (IBS)
◆ Infectious disease (e.g. Diarrhea)
◆ Functional Bowel Disorders (FBD)
◆ Celiac disease
◆ Pouchitis
◆ Intestinal mucositis
◆ Other gastrointestinal disorders
Dietary interventions, fecal transplantation, antibiotics, probiotics, prebiotics, and symbiotics are all potential therapeutic options, as well as aiming at certain therapeutic targets and pathways. Methods implemented for each condition and even on different individual could vary a lot, which could be influenced by multiple factors including but not limited to host age, diet, hormone secretion, immune system functions, gut epithelial dysfunction and of course the microbiota side ones including dysbiosis, bacteria translocation, and the production of key metabolites. Promising examples would be probiotics use in various gastrointestinal disorders such as infectious disease, pouchitis, Crohn's disease, prebiotics and probiotics use in FBD, and fecal microbiota transplant in gut microbiota dysbiosis.
CD Genomics is a preeminent corporation that specializes in multi-omics. Equipped with cutting-edge techniques and served by well-experienced scientists, we have extensive experience dealing with all kinds of difficulties you may have encountered in your research, and we will provide the most valid and state-of-the-art solutions to meet your needs – We can help you raise understanding of the role of the microbiota and allowing for further research; we can provide insight into which features and what contributions the microbiota make that are essential to host physiology; we can assist you in explaining the mechanisms that microbiota interacts with the host; we can combine the basic research with exploring therapeutic methods that target at gut microbiota…
CD Genomics dedicates to providing the highest level of solutions in gut microbiota research. We will offer the most suitable strategies according to your sample and research purpose. To find out more solutions for gut microbiota and gastrointestinal diseases, please feel free to contact us.
*For Research Use Only. Not for use in diagnostic procedures.