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Maximize resolution and minimize sequencing costs with our Targeted 3D Genomics & Capture Services. From genome-wide Promoter Capture Panels for variant interpretation to ultra-high-resolution Tri-C for single-locus dissection, we provide a complete suite of enrichment strategies. Focus your sequencing power exactly where it matters—on your specific genes, GWAS intervals, or regulatory elements. RUO.
Genome-wide Hi-C provides a global map of chromatin architecture, but for many research questions, "global" is not enough. When the goal is to fine-map a specific GWAS interval, dissect the regulatory logic of a gene cluster, or validate CRISPR-mediated structural changes, standard Hi-C often lacks the sequencing depth required to resolve fine-scale loops.
Our Targeted 3D Genomics & Capture Services solve this coverage-versus-cost dilemma. By using enrichment strategies—either hybridization-based capture or viewpoint-specific selection—we allow you to focus your sequencing reads exclusively on the genomic regions that matter to your research.
This targeted approach yields ultra-high resolution (1–5 kb or restriction fragment level) interaction maps at a fraction of the cost of deep whole-genome sequencing. Whether you need to map the interactome of thousands of promoters simultaneously or dissect the complex folding of a single developmental locus, our portfolio offers the precise tool for the job.
Targeted 3D genomics encompasses two distinct technical approaches: Hybridization Capture (using probes to pull down targets from a Hi-C library) and Viewpoint Selection (using PCR to amplify interactions from specific anchors). Use this guide to navigate to the correct service.
These methods utilize biotinylated RNA or DNA probes to enrich a standard Hi-C library for specific sequences of interest. They are ideal for high-throughput targeting of discontinuous regions.
Custom Probe Design. We design custom probe sets to enrich Hi-C libraries for your specific regions of interest—whether it's a list of 500 differentially expressed genes or a set of GWAS risk intervals. Obtain genome-wide interaction maps specifically for your targets.
Off-the-Shelf Efficiency. Available for Human and Mouse genomes. These pre-designed panels target the promoters of all annotated coding genes, allowing you to map the "Promoterome" and link distal enhancers to their target genes without custom design costs.
These methods do not use hybridization probes. Instead, they use specific oligonucleotide primers to selectively amplify ligation junctions involving your "viewpoint" (anchor) of interest. They offer the highest possible resolution per locus.
High-Throughput Viewpoints. Uses oligonucleotide capture to profile interactions for hundreds of viewpoints simultaneously. Excellent for characterizing the regulatory landscape of gene pathways.
Cost-Effective Regional Mapping. A robust method using selective PCR and ligation to map all interactions within a specific chromosomal region. Ideal for deep analysis of specific TADs.
Multi-Way Interactions. A specialized variant of Chromosome Conformation Capture designed to detect simultaneous, multi-way interactions (hubs) involving a specific locus.
| Feature | Hybridization (e.g., CHi-C) | Viewpoint Selection (e.g., Capture-C) |
|---|---|---|
| Throughput | High (Thousands of targets) | Low to Medium (1–100 targets) |
| Resolution | High (Fragment level) | Ultra-High (Single restriction site) |
| Start-Up Cost | Higher (Requires probe synthesis) | Lower (Requires primer synthesis) |
| Sequencing Depth | Moderate efficiency (Off-target reads possible) | High efficiency (Near-total enrichment) |
| Best Application | Genome-wide surveys (Promoterome, GWAS) | Deep dissection of specific loci |
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