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Integrated Analysis of Transcriptomic And Proteomic Data From Tree Peony (P. ostii) Seeds Reveals Key Developmental Stages And Candidate Genes Related to Oil Biosynthesis And Fatty Acid Metabolism October 1, 2019

Tree peony (Paeonia section Moutan DC.) seeds are an excellent source of beneficial natural compounds that promote health, and they contain high levels of alpha-linolenic acid (ALA). In recent years, tree peony has been emerging as an oil crop. Therefore, combined analysis......

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Gene Editing Has Been Used Successfully on Reptiles-Albino Lizards September 26, 2019

Although birds, mammals and fish have been successfully edited with CRISPR, reptiles have proved more challenging targets for the CRISPR/Cas-9 system due to the differences in their reproductive physiology. The brown anole lizard, Anolis sagrei......

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Long-read Assembly of The Chinese Rhesus Macaque Genome And Identification of Ape-specific Structural Variants September 17, 2019

We present a high-quality de novo genome assembly (rheMacS) of the Chinese rhesus macaque (Macaca mulatta) using long-read sequencing and multiplatform scaffolding approaches. Compared to the current Indian rhesus macaque reference genome (rheMac8), rheMacS......

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A High-resolution 3D Epigenomic Map Reveals Insights Into The Creation of The Prostate Cancer Transcriptome September 12, 2019

To better understand the impact of chromatin structure on regulation of the prostate cancer transcriptome, we develop high-resolution chromatin interaction maps in normal and prostate cancer cells using in situ Hi-C. By combining the in situ Hi-C data with active and repressive histone marks, CTCF binding sites......

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Gene That Linked with Natural Short Sleep Has Been Identified September 3, 2019

Back in 2009 the researchers discovered that those with a mutation in their DEC2 gene averaged 6.25 hours sleep per night, compared to 8.06 hours in those without the mutation. 10 years later, researchers have now discovered another mutation, ADRB1 gene, that allows members of a family......

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Uncovering the Biosynthetic Potential of Rare Metagenomic DNA Using Co-occurrence Network Analysis of Targeted Sequences August 26, 2019

Sequencing of DNA extracted from environmental samples can provide key insights into the biosynthetic potential of uncultured bacteria. However, the high complexity of soil metagenomes, which can contain thousands of bacterial species per gram of soil, imposes significant challenges......

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Systematic Identification and Characterization of Aedes Aegypti Long Noncoding RNAs (lncRNAs) August 21, 2019

Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisation......

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Genetic Mutation Significantly Extend Fruit Fly Lifespan August 12, 2019

Fruit flies share a significant proportion of their genes with humans, making them good models to study human diseases and ageing. As the fruit flies usually live for about two months their lifespan is easy to measure. Fruit Flies with a mutation known as E(z) were shown......

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The Transcriptome of Darwin’s Bark Spider Silk Glands Predicts Proteins Contributing to Dragline Silk Toughness July 25, 2019

Darwin's bark spider (Caerostris darwini) produces giant orb webs from dragline silk that can be twice as tough as other silks, making it the toughest biological material. This extreme toughness comes from increased extensibility relative to other draglines. We show C. darwinidragline-producing major ampullate (MA)......

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Researchers Discover Gender Affects Gene Expression in Mammals July 22, 2019

Researchers have discovered genome-wide variations in gene expression between male and female mammals. Although it has been known that different genes determine different characteristics in male and females, new research suggests that differences in gene expression has......

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