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Researchers Discover Gender Affects Gene Expression in Mammals Jul 22/2019

Jul 22, 2019 Researchers have discovered genome-wide variations in gene expression between male and female mammals. Although it has been known that different genes determine different characteristics ......

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Scientists Have Edited Plant Mitochondrial DNA for The First Time Jul 11/2019

Jul 11, 2019 Nuclear DNA was first edited in the early 1970s, chloroplast DNA was first edited in 1988, and animal mitochondrial DNA was edited in 2008. However, no tool previously successfully edited......

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Fleeting Genetic Changes Could Have Lasting Impact Jul 2/2019

Jul 2, 2019 Scientists studying stem cell differentiation usually only compare the differences in gene expression between the fully undifferentiated and differentiated cells. However, new research has......

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Sequencing cell-type-specific transcriptomes with SLAM-ITseq Jun 26/2019

Jun 26, 2019 Wayo Matsushima, Veronika A. Herzog, Tobias Neumann, Katharina Gapp, Johannes Zuber, Stefan L. Ameres & Eric A. Miska Nature Protocols 14, 2261–2278 (2019) SLAM-ITseq design. Schematic of......

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Scientists Develop a Primate Model for Autism by Genome-Editing Jun 16/2019

Jun 16, 2019 A China-U.S. joint research team has engineered macaque monkeys to express a mutation linked to autism and other human neurodevelopmental disorders, through the genome-editing system CRIS......

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Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data Jun 4/2019

Jun 4, 2019 Qian Liu, Li Fang, Guoliang Yu, Depeng Wang, Chuan-Le Xiao & Kai Wang Nature Communications 10, Article number: 2449 (2019) Abstract DNA base modifications, such as C5-methylcytosine (5mC)......

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An ATAC-seq atlas of chromatin accessibility in mouse tissues May 20/2019

May 20, 2019 Chuanyu Liu, Mingyue Wang, Xiaoyu Wei, Liang Wu, Jiangshan Xu, Xi Dai, Jun Xia, Mengnan Cheng, Yue Yuan, Pengfan Zhang, Jiguang Li, Taiqing Feng, Ao Chen, Wenwei Zhang, Fang Chen, Zhouchu......

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Hydro-Seq Improves Circulating Tumor Cells Analysis by High-Throughput scRNA-seq May 16/2019

May 16, 2019 Clean separation of cancer cells from a patient’s blood sample has been an ongoing challenge for the liquid biopsy field. The ability to perform molecular analysis on circulating tumor ce......

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Lasy-Seq: a high-throughput library preparation method for RNA-Seq and its application in the analysis of plant responses to fluctuating temperatures May 8/2019

May 8, 2019 Mari Kamitani, Makoto Kashima, Ayumi Tezuka & Atsushi J. Nagano Scientific Reports 9, Article number: 7091 (2019) Comparison of the RNA-Seq library preparation methods. Steps modified in L......

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Researchers Find A New Generation of Regenerative Treatments in Humans August 1/2019

  August 1, 2019 The genes that enable a fish to re-grow limbs have been found to be present in humans, new research has found. This insight could help develop regenerative treatments in humans. ......

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