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Top 10 Most-Read Genomics News Stories of 2019 December 20, 2019

Our most popular news story – the new blood test that can detect multiple cancer types with a high degree of accuracy. The test focused on analysing epigenetic markers in cancer DNA present in the blood, with trials showing a 99.4% specificity when using the test. It can also detect......

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Autoimmune Issues Could be Linked to Extra X Chromosome in Females December 12, 2019

Researchers have discovered a possible explanation for why autoimmune disease are more common in females. The research, Published in the Proceedings of the National Academy of Sciences, USA, based on mouse models showed that the Double XX chromosome in females may be to blame.......

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Trio Deep-sequencing Does Not Reveal Unexpected Off-target and On-target Mutations in Cas9-edited Rhesus Monkeys December 4, 2019

CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect and on-target complex mutations remain a concern, especially in view of future clinical applications. Non-human primates (NHPs) share close genetic and physiological similarities with humans, making them......

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Gut Microbiota Imbalance Promotes the Onset of Colorectal Cancer November 26, 2019

Sporadic Colorectal Cancer is one of the most common cancers worldwide with over 42,000 cases a year in the UK and a 57% survival rate over ten years. The exact causes of colorectal cancer are unknown, but gut microbiota were investigated as a potential link between diet, environmental stresses, and colon......

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The New Way to Translate A Dog’s Age into Human Years November 18, 2019

Over 100,000 people die each day from age-related causes and the mechanisms are poorly understood. The main factors implicated are cell death, DNA damage and DNA methylation. Whether these factors are part of development or due to our environment is up for debate.......

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Ultralow Amounts of DNA from Long-term Archived Serum Samples Produce Quality Genotypes November 12, 2019

While genotyping studies are scavenging for suitable samples to analyze, large serum collections are currently left unused as they are assumed to provide insufficient amounts of DNA for array-based genotyping. Long-term stored serum is considered to be......

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Full-length Transcriptome Reconstruction Reveals A Large Diversity of RNA And Protein Isoforms in Rat Hippocampus November 1, 2019

The flow chart of the hybrid sequencing workflow, including the experimental procedures (blue rectangles) comprised of PacBio sequencing and Illumina sequencing, and the computational components (pink rectangles) for Illumina-based PacBio error correction, followed by......

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A New Gene Editing Tool That Can Reverse Harmful Mutations October 28, 2019

Currently the CRISPR Cas-9 system is the most widely used gene editing technique. It works by making double stranded DNA breaks, which can result in multiple insertions and deletions taking place; both near the cut site and at other DNA sequences which resemble the targeted gene. It is possible that these 'off target mutations'......

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ATCC Launched Its New Reference-Quality Genomes October 18, 2019

Manassas, VA – October 1, 2019 –ATCC launched its new ATCC Genome Portal, a publicly available database of reference-quality genome sequences matched to authenticated ATCC biological materials that will help researchers interpret and reproduce their results with confidence. The portal, which launched with an initial......

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A Systematic Evaluation of Single Cell RNA-seq Analysis Pipelines October 11, 2019

The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variety of experimental and computational pipelines for which best practices have not yet been established. Here, we use simulations based on five scRNA-seq library protocols in combination with nine realistic differential expression......

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