Based on MGI's (part of BGI Group) unique technology DNBSEQ, different sequencers are developed. They benefit from the advantages of low amplification error rate from DNBs (DNA nanoballs) and high-density Patterned Arrays to significantly improve the accuracy of sequencing with a low repetition rate. Combined with the PCR-free library preparation approach, it reduces the error of entry during amplification and greatly improves the accuracy of detecting SNPs and indels.
MGI Sequencers include various types of sequencing instruments to meet the needs of different samples and applications.
|Services||MGI Sequencers||Sequencing Type|
|Variant Calling (SNV & CNV & Indel)||DNBSEQ-G400||SE50|
|Whole Genome Sequencing (WGS)||DNBSEQ-G400/DNBSEQ-T7||SE100/PE100/PE150/PE200/SE400|
|Whole Exome Sequencing (WES)||PE100/PE150|
|Small RNA Seq||DNBSEQ-G400||SE50|
|Whole Genome Bisulfite Sequencing (WGBS)||DNBSEQ-G400||PE100/PE150|
Sequencing starts with the hybridization of a DNA anchor, followed by ligation of fluorescently labeled probes to DNBs using the combinatorial Probe Anchor Synthesis (cPAS) technology. Finally, a high-resolution imaging system captures the fluorescent signal. Those sequencers digitize the optical signal to produce high-quality, high-precision sequencing information.