MGI Sequencers (DNBSEQ-T7/DNBSEQ-G400)

Based on MGI's (part of BGI Group) unique technology DNBSEQ, different sequencers are developed. They benefit from the advantages of low amplification error rate from DNBs (DNA nanoballs) and high-density Patterned Arrays to significantly improve the accuracy of sequencing with a low repetition rate. Combined with the PCR-free library preparation approach, it reduces the error of entry during amplification and greatly improves the accuracy of detecting SNPs and indels.

MGI Sequencers include various types of sequencing instruments to meet the needs of different samples and applications.

DNBSEQ-T7

• High speed: 24~30 hours of sequencing with PE150
• High flexibility: supports up to 4 flow cells, PE150 and PE100 simultaneously
• Ultra-high throughput: up to 6 TB per day
• Applications: whole genome sequencing (human, animals and plant WGS), whole exome sequencing, transcriptome sequencing, epigenome sequencing and targeted panel sequencing

DNBSEQ-G400

• High speed: only 38 hours at full capacity (PE150 sequencing)
• High flexibility: wide choices of read lengths, from SE50 to SE400/PE200
• High throughput: up to 1440 GB per run
• Applications: whole genome sequencing (human, animals and plant WGS), microbial sequencing, whole exome sequencing, transcriptome sequencing and targeted panel sequencing, etc.

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DNBSEQ Technology

Sequencing starts with the hybridization of a DNA anchor, followed by ligation of fluorescently labeled probes to DNBs using the combinatorial Probe Anchor Synthesis (cPAS) technology. Finally, a high-resolution imaging system captures the fluorescent signal. Those sequencers digitize the optical signal to produce high-quality, high-precision sequencing information.