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ChIP-on-chip Service

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CD Genomics provides complete ChIP-on-chip service from sample to results. This service which is available to academic and commercial researchers, employs some of the most famous microarray platform in this field. 

ChIP-on-chip combines Chromatin Immunoprecipitation (ChIP) with microarray technology to analyze how regulatory proteins interact with the genome and provide insight into the mechanisms for histone modification and regulation of transcription factors.

Features and Benefits

  • Comprehensive genome-wide and focused coverage
  • Superior microarray performance and capability 
  • Greater confidence in binding event data 
  • Flexible and versatile user-defined microarray formats 
  • Greater confidence in binding event data 
  • Quick turnaround 
  • Easy-to-use data analysis software 
  • Access to probe sequence and annotation information

Workflow of Our Service

ChIP-on-chip workflowWorkflow of ChIP-on-chip service

Applications of Our Service

  • Uncover and validate gene regulation and regulatory networks by comprehensive determination of promoter occupancy.
  • Identify and characterize molecular events associated with processes for transcription, DNA replication and repair, as well as with chromatin modifications and DNA methylation.
  • Elucidate modes of action and potential therapeutic activities of compounds and target genes by mapping gene regulatory networks relevant to disease and pathophysiological states.
  • Validate and augment existing gene expression data with authentic binding events.
  • Identify, assess, and monitor biomarkers response to protein-DNA binding events to serve as bioassays or toxicant signatures for toxicogenomics.
  • Uncover and profile off-target events as well as validate primary and secondary effects in screening of candidate compounds, siRNAs, therapeutics, etc.

Recommendations and Custom Service

Table 1 Agilent ChIP-on-chip Arrays

Microarray

Species

Format(s)

Coverage

SurePrint G3 Human Promoter Array

Human

1 х 1M

21,000 RefSeq transcripts

SurePrint G3 Mouse Promoter Array

Mouse

1 х 1M

19,000 RefSeq transcripts

Others (please click here )

-

-

-

Table 2 Affymetrix ChIP-on-chip Arrays

Microarray

Species

Unite size

Coverage

Human Promoter 1.0R Array

Human

2 arrays

25,500 RefSeq promoters (-2.45 kb~ +2.75 kb)

Mouse Promoter 1.0R Array

Mouse

2 arrays

28,000 RefSeq promoters (-2.5 kb~ +6 kb)

Others

-

-

-

CD Genomics can also help create your own custom microarray. We are ready to help you with your custom array needs, whether it’s a standard design or something more creative.

For more details, please feel free to contact us with any questions at any time by completing a no obligation quote request.

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CONTACT CD GENOMICS

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-275-3058
Fax: 1-631-614-7828
Email: info@cd-genomics.com